diff --git a/test/functional/feature_deterministic_chain_setup.py b/test/functional/feature_deterministic_chain_setup.py
new file mode 100644
--- /dev/null
+++ b/test/functional/feature_deterministic_chain_setup.py
@@ -0,0 +1,92 @@
+#!/usr/bin/env python3
+# Copyright (c) 2022 The Bitcoin developers
+# Distributed under the MIT software license, see the accompanying
+# file COPYING or http://www.opensource.org/licenses/mit-license.php.
+"""This test reproduces the unittest deterministic chain setup and verifies
+the checkpoints and coinstatindexes."""
+
+from test_framework.key import ECKey
+from test_framework.messages import (
+    COIN,
+    CBlock,
+    COutPoint,
+    CTransaction,
+    CTxIn,
+    CTxOut,
+)
+from test_framework.script import OP_CHECKSIG, CScript, CScriptNum, CScriptOp
+from test_framework.test_framework import BitcoinTestFramework
+from test_framework.util import assert_equal
+
+INITIAL_MOCKTIME = 1598887952
+
+
+def get_coinbase_scriptsig(height: int) -> bytes:
+    OP_1 = 0x51
+    if height <= 16:
+        bip34_coinbase_height = bytes([OP_1 + height - 1])
+    else:
+        bip34_coinbase_height = CScriptNum.encode(CScriptNum(height))
+    extra_nonce = CScriptNum.encode(CScriptNum(1))
+    excessive_blocksize_sig = CScriptOp.encode_op_pushdata(b'/EB32.0/')
+    return bip34_coinbase_height + extra_nonce + excessive_blocksize_sig
+
+
+def get_coinbase(height: int, pubkey: bytes) -> CTransaction:
+    coinbase = CTransaction()
+    coinbase.nVersion = 2
+    coinbase.vin.append(CTxIn(COutPoint(0, 0xffffffff),
+                              get_coinbase_scriptsig(height),
+                              0xffffffff))
+    coinbaseoutput = CTxOut()
+    coinbaseoutput.nValue = 50 * COIN
+    regtest_halvings = int(height / 150)
+    coinbaseoutput.nValue >>= regtest_halvings
+    coinbaseoutput.scriptPubKey = CScript([pubkey, OP_CHECKSIG])
+    coinbase.vout = [coinbaseoutput]
+    coinbase.calc_sha256()
+    return coinbase
+
+
+def get_empty_block(height: int, base_block_hash: str, block_time: int,
+                    coinbase_pubkey: bytes) -> CBlock:
+    block = CBlock()
+    block.nVersion = 0x20000000
+    block.nTime = block_time
+    block.hashPrevBlock = int(base_block_hash, 16)
+    # difficulty retargeting is disabled in REGTEST chainparams
+    block.nBits = 0x207fffff
+    block.vtx.append(get_coinbase(height, coinbase_pubkey))
+    block.hashMerkleRoot = block.calc_merkle_root()
+    block.solve()
+    return block
+
+
+class DeterministicChainSetupTest(BitcoinTestFramework):
+    def set_test_params(self):
+        self.num_nodes = 1
+        self.setup_clean_chain = True
+
+    def run_test(self):
+        node = self.nodes[0]
+        genesis_hash = node.getbestblockhash()
+
+        coinbase_key = ECKey()
+        coinbase_key.set(31 * b"\x00" + b"\x01", compressed=False)
+        coinbase_pubkey = coinbase_key.get_pubkey().get_bytes()
+
+        tip = genesis_hash
+        for i in range(100):
+            block = get_empty_block(i + 1, tip, INITIAL_MOCKTIME + i,
+                                    coinbase_pubkey)
+            assert node.submitblock(block.serialize().hex()) is None
+            tip = node.getbestblockhash()
+
+        self.log.info(
+            "Reproduce the assertion in the TestChain100Setup constructor.")
+        assert_equal(tip,
+                     "7709f3c48b74400f751dc88fcb318431cbe43f2284c43d830775defb89b50168")
+
+
+if __name__ == '__main__':
+    DeterministicChainSetupTest().main()