diff --git a/src/node/coinstats.h b/src/node/coinstats.h
--- a/src/node/coinstats.h
+++ b/src/node/coinstats.h
@@ -39,7 +39,10 @@
     //! The number of coins contained.
     uint64_t coins_count{0};
 
-    bool from_index{false};
+    //! Signals if the coinstatsindex should be used (when available).
+    bool index_requested{true};
+    //! Signals if the coinstatsindex was used to retrieve the statistics.
+    bool index_used{false};
 
     // Following values are only available from coinstats index
     Amount total_subsidy{Amount::zero()};
diff --git a/src/node/coinstats.cpp b/src/node/coinstats.cpp
--- a/src/node/coinstats.cpp
+++ b/src/node/coinstats.cpp
@@ -103,12 +103,12 @@
     stats.nHeight = Assert(pindex)->nHeight;
     stats.hashBlock = pindex->GetBlockHash();
 
-    // Use CoinStatsIndex if it is available and a hash_type of Muhash or None
-    // was requested
+    // Use CoinStatsIndex if it is requested and available and a hash_type of
+    // Muhash or None was requested
     if ((stats.m_hash_type == CoinStatsHashType::MUHASH ||
          stats.m_hash_type == CoinStatsHashType::NONE) &&
-        g_coin_stats_index) {
-        stats.from_index = true;
+        g_coin_stats_index && stats.index_requested) {
+        stats.index_used = true;
         return g_coin_stats_index->LookUpStats(pindex, stats);
     }
 
diff --git a/src/rpc/blockchain.cpp b/src/rpc/blockchain.cpp
--- a/src/rpc/blockchain.cpp
+++ b/src/rpc/blockchain.cpp
@@ -1297,6 +1297,8 @@
              "with coinstatsindex).",
              "",
              {"", "string or numeric"}},
+            {"use_index", RPCArg::Type::BOOL, /* default */ "true",
+             "Use coinstatsindex, if available."},
         },
         RPCResult{
             RPCResult::Type::OBJ,
@@ -1377,6 +1379,8 @@
                     ? CoinStatsHashType::HASH_SERIALIZED
                     : ParseHashType(request.params[0].get_str())};
             CCoinsStats stats{hash_type};
+            stats.index_requested =
+                request.params[2].isNull() || request.params[2].get_bool();
 
             NodeContext &node = EnsureAnyNodeContext(request.context);
             ChainstateManager &chainman = EnsureChainman(node);
@@ -1416,7 +1420,7 @@
                     ret.pushKV("muhash", stats.hashSerialized.GetHex());
                 }
                 ret.pushKV("total_amount", stats.nTotalAmount);
-                if (!stats.from_index) {
+                if (!stats.index_used) {
                     ret.pushKV("transactions",
                                static_cast<int64_t>(stats.nTransactions));
                     ret.pushKV("disk_size", stats.nDiskSize);
diff --git a/src/rpc/client.cpp b/src/rpc/client.cpp
--- a/src/rpc/client.cpp
+++ b/src/rpc/client.cpp
@@ -112,6 +112,7 @@
     {"gettxout", 2, "include_mempool"},
     {"gettxoutproof", 0, "txids"},
     {"gettxoutsetinfo", 1, "hash_or_height"},
+    {"gettxoutsetinfo", 2, "use_index"},
     {"lockunspent", 0, "unlock"},
     {"lockunspent", 1, "transactions"},
     {"send", 0, "outputs"},
diff --git a/test/functional/feature_coinstatsindex.py b/test/functional/feature_coinstatsindex.py
--- a/test/functional/feature_coinstatsindex.py
+++ b/test/functional/feature_coinstatsindex.py
@@ -40,6 +40,7 @@
 
     def run_test(self):
         self._test_coin_stats_index()
+        self._test_use_index_option()
 
     def block_sanity_check(self, block_info):
         block_subsidy = 50_000_000
@@ -254,6 +255,17 @@
         res10 = index_node.gettxoutsetinfo('muhash')
         assert(res8['txouts'] < res10['txouts'])
 
+    def _test_use_index_option(self):
+        self.log.info("Test use_index option for nodes running the index")
+
+        self.connect_nodes(0, 1)
+        self.nodes[0].waitforblockheight(110)
+        res = self.nodes[0].gettxoutsetinfo('muhash')
+        option_res = self.nodes[1].gettxoutsetinfo(
+            hash_type='muhash', hash_or_height=None, use_index=False)
+        del res['disk_size'], option_res['disk_size']
+        assert_equal(res, option_res)
+
 
 if __name__ == '__main__':
     CoinStatsIndexTest().main()