diff --git a/CMakeLists.txt b/CMakeLists.txt
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -12,8 +12,8 @@
 # If ccache is available, then use it.
 find_program(CCACHE ccache)
 if(CCACHE)
-    set_property(GLOBAL PROPERTY RULE_LAUNCH_COMPILE ${CCACHE})
-    set_property(GLOBAL PROPERTY RULE_LAUNCH_LINK ${CCACHE})
+	set_property(GLOBAL PROPERTY RULE_LAUNCH_COMPILE ${CCACHE})
+	set_property(GLOBAL PROPERTY RULE_LAUNCH_LINK ${CCACHE})
 endif(CCACHE)
 
 # Add the magic taret check and check-all
diff --git a/cmake/modules/BrewHelper.cmake b/cmake/modules/BrewHelper.cmake
new file mode 100644
--- /dev/null
+++ b/cmake/modules/BrewHelper.cmake
@@ -0,0 +1,21 @@
+# Copyright (c) 2018 The Bitcoin developers
+
+find_program(BREW brew)
+
+function(find_brew_prefix VAR NAME)
+	if(NOT BREW)
+		return()
+	endif()
+
+	if(DEFINED ${VAR})
+		return()
+	endif()
+
+	execute_process(
+		COMMAND ${BREW} --prefix ${NAME}
+		OUTPUT_VARIABLE PREFIX
+		ERROR_QUIET
+		OUTPUT_STRIP_TRAILING_WHITESPACE
+	)
+	set(${VAR} ${PREFIX} PARENT_SCOPE)
+endfunction()
diff --git a/cmake/modules/FindBerkeleyDB.cmake b/cmake/modules/FindBerkeleyDB.cmake
--- a/cmake/modules/FindBerkeleyDB.cmake
+++ b/cmake/modules/FindBerkeleyDB.cmake
@@ -5,11 +5,30 @@
 # BDBXX_INCLUDE_DIR - the Berkeley DB include directory for C++
 # BDBXX_LIBRARY - Library needed to use Berkeley DB C++ API
 
-find_path(BDB_INCLUDE_DIR NAMES db.h)
-find_library(BDB_LIBRARY NAMES db libdb)
+include(BrewHelper)
+find_brew_prefix(BREW_HINT berkeley-db)
 
-find_path(BDBXX_INCLUDE_DIR NAMES db_cxx.h)
-find_library(BDBXX_LIBRARY NAMES db_cxx libdb_cxx)
+find_path(BDB_INCLUDE_DIR
+	NAMES
+		db.h
+	HINTS ${BREW_HINT}
+)
+find_library(BDB_LIBRARY
+	NAMES
+		db libdb
+	HINTS ${BREW_HINT}
+)
+
+find_path(BDBXX_INCLUDE_DIR
+	NAMES
+		db_cxx.h
+	HINTS ${BREW_HINT}
+)
+find_library(BDBXX_LIBRARY
+	NAMES
+		db_cxx libdb_cxx
+	HINTS ${BREW_HINT}
+)
 
 MESSAGE(STATUS "BerkeleyDB libs: " ${BDB_LIBRARY} " " ${BDBXX_LIBRARY})
 
diff --git a/src/config/CMakeLists.txt b/src/config/CMakeLists.txt
--- a/src/config/CMakeLists.txt
+++ b/src/config/CMakeLists.txt
@@ -110,6 +110,8 @@
 check_symbol_exists(strnlen "string.h" HAVE_DECL_STRNLEN)
 
 # OpenSSL functionality
+include(BrewHelper)
+find_brew_prefix(OPENSSL_ROOT_DIR openssl)
 find_package(OpenSSL REQUIRED)
 set(CMAKE_REQUIRED_INCLUDES ${OPENSSL_CRYPTO_INCLUDES})
 set(CMAKE_REQUIRED_LIBRARIES ${OPENSSL_CRYPTO_LIBRARY})
diff --git a/src/crypto/CMakeLists.txt b/src/crypto/CMakeLists.txt
--- a/src/crypto/CMakeLists.txt
+++ b/src/crypto/CMakeLists.txt
@@ -32,5 +32,7 @@
 endif()
 
 # Dependencies
+include(BrewHelper)
+find_brew_prefix(OPENSSL_ROOT_DIR openssl)
 find_package(OpenSSL REQUIRED)
 target_link_libraries(crypto ${OPENSSL_CRYPTO_LIBRARY})
diff --git a/src/qt/CMakeLists.txt b/src/qt/CMakeLists.txt
--- a/src/qt/CMakeLists.txt
+++ b/src/qt/CMakeLists.txt
@@ -5,7 +5,9 @@
 # This ensure that AUTOMOC doesn't run on generated files.
 cmake_policy(SET CMP0071 OLD)
 
-find_package(Qt5 COMPONENTS Widgets Network REQUIRED)
+include(BrewHelper)
+find_brew_prefix(QT5_PREFIX qt5)
+find_package(Qt5 COMPONENTS Widgets Network REQUIRED HINTS "${QT5_PREFIX}")
 
 # Localisation
 add_subdirectory(locale)
@@ -112,6 +114,8 @@
 		${CMAKE_CURRENT_BINARY_DIR}
 		${CMAKE_CURRENT_BINARY_DIR}/forms
 		${Protobuf_INCLUDE_DIRS}
+	PRIVATE
+		${OPENSSL_INCLUDE_DIR}
 )
 
 target_link_libraries(bitcoin-qt-base
@@ -161,6 +165,9 @@
 	target_link_libraries(bitcoin-qt-base wallet)
 
 	# Dependencies
+	# Support Brew OpenSSL on MacOS X
+	include(BrewHelper)
+	find_brew_prefix(OPENSSL_ROOT_DIR openssl)
 	find_package(OpenSSL REQUIRED)
 	target_link_libraries(bitcoin-qt-base ${OPENSSL_CRYPTO_LIBRARY})
 endif()
diff --git a/src/qt/locale/CMakeLists.txt b/src/qt/locale/CMakeLists.txt
--- a/src/qt/locale/CMakeLists.txt
+++ b/src/qt/locale/CMakeLists.txt
@@ -2,7 +2,10 @@
 
 project(bitcoin-qt-locale)
 
-find_package(Qt5LinguistTools)
+include(BrewHelper)
+find_brew_prefix(QT5_PREFIX qt5)
+
+find_package(Qt5LinguistTools HINTS "${QT5_PREFIX}")
 
 qt5_add_translation(BITCOIN_QM_FILES
 	bitcoin_af.ts