diff --git a/CMakeLists.txt b/CMakeLists.txt
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -9,11 +9,17 @@
 	${CMAKE_CURRENT_SOURCE_DIR}/cmake/modules
 )
 
+# Support Brew OpenSSL on MacOS X
+include(BrewHelper)
+if(NOT DEFINED OPENSSL_ROOT_DIR)
+	find_brew_prefix(OPENSSL_ROOT_DIR openssl)
+endif()
+
 # If ccache is available, then use it.
 find_program(CCACHE ccache)
 if(CCACHE)
-    set_property(GLOBAL PROPERTY RULE_LAUNCH_COMPILE ${CCACHE})
-    set_property(GLOBAL PROPERTY RULE_LAUNCH_LINK ${CCACHE})
+	set_property(GLOBAL PROPERTY RULE_LAUNCH_COMPILE ${CCACHE})
+	set_property(GLOBAL PROPERTY RULE_LAUNCH_LINK ${CCACHE})
 endif(CCACHE)
 
 # Add the magic taret check and check-all
diff --git a/cmake/modules/BrewHelper.cmake b/cmake/modules/BrewHelper.cmake
new file mode 100644
--- /dev/null
+++ b/cmake/modules/BrewHelper.cmake
@@ -0,0 +1,26 @@
+# Copyright (c) 2018 The Bitcoin developers
+
+find_program(BREW brew)
+
+function(find_brew_prefix VAR NAME)
+	if(NOT BREW)
+		return()
+	endif()
+
+	if(DEFINED ${VAR})
+		return()
+	endif()
+
+	if(DEFINED "BREW_CACHED_PREFIX_${NAME}")
+		set(${VAR} ${BREW_CACHED_PREFIX_${NAME}} PARENT_SCOPE)
+	endif()
+
+	execute_process(
+		COMMAND ${BREW} --prefix ${NAME}
+		OUTPUT_VARIABLE PREFIX
+		ERROR_QUIET
+		OUTPUT_STRIP_TRAILING_WHITESPACE
+	)
+	set("BREW_CACHED_PREFIX_${NAME}" ${PREFIX} CACHE PATH "Path for ${NAME} within brew")
+	set(${VAR} ${PREFIX} PARENT_SCOPE)
+endfunction()
diff --git a/cmake/modules/FindBerkeleyDB.cmake b/cmake/modules/FindBerkeleyDB.cmake
--- a/cmake/modules/FindBerkeleyDB.cmake
+++ b/cmake/modules/FindBerkeleyDB.cmake
@@ -5,11 +5,30 @@
 # BDBXX_INCLUDE_DIR - the Berkeley DB include directory for C++
 # BDBXX_LIBRARY - Library needed to use Berkeley DB C++ API
 
-find_path(BDB_INCLUDE_DIR NAMES db.h)
-find_library(BDB_LIBRARY NAMES db libdb)
+include(BrewHelper)
+find_brew_prefix(BREW_HINT berkeley-db)
 
-find_path(BDBXX_INCLUDE_DIR NAMES db_cxx.h)
-find_library(BDBXX_LIBRARY NAMES db_cxx libdb_cxx)
+find_path(BDB_INCLUDE_DIR
+	NAMES
+		db.h
+	HINTS ${BREW_HINT}
+)
+find_library(BDB_LIBRARY
+	NAMES
+		db libdb
+	HINTS ${BREW_HINT}
+)
+
+find_path(BDBXX_INCLUDE_DIR
+	NAMES
+		db_cxx.h
+	HINTS ${BREW_HINT}
+)
+find_library(BDBXX_LIBRARY
+	NAMES
+		db_cxx libdb_cxx
+	HINTS ${BREW_HINT}
+)
 
 MESSAGE(STATUS "BerkeleyDB libs: " ${BDB_LIBRARY} " " ${BDBXX_LIBRARY})
 
diff --git a/src/qt/locale/CMakeLists.txt b/src/qt/locale/CMakeLists.txt
--- a/src/qt/locale/CMakeLists.txt
+++ b/src/qt/locale/CMakeLists.txt
@@ -2,7 +2,10 @@
 
 project(bitcoin-qt-locale)
 
-find_package(Qt5LinguistTools)
+include(BrewHelper)
+find_brew_prefix(QT5_PREFIX qt5)
+
+find_package(Qt5LinguistTools HINTS "${QT5_PREFIX}")
 
 qt5_add_translation(BITCOIN_QM_FILES
 	bitcoin_af.ts