diff --git a/cmake/platforms/OSX.cmake b/cmake/platforms/OSX.cmake
new file mode 100644
--- /dev/null
+++ b/cmake/platforms/OSX.cmake
@@ -0,0 +1,42 @@
+# Copyright (c) 2017 The Bitcoin developers
+
+set(CMAKE_SYSTEM_NAME Darwin)
+set(TOOLCHAIN_PREFIX x86_64-apple-darwin11)
+
+# On OSX, we use clang by default.
+set(CMAKE_C_COMPILER clang)
+set(CMAKE_CXX_COMPILER clang++)
+# set(CMAKE_CXX_EXTENSIONS OFF)
+
+# On OSX we use various stuff from Apple's SDK.
+set(OSX_SDK_PATH "${CMAKE_CURRENT_SOURCE_DIR}/depends/SDKs/MacOSX10.11.sdk")
+
+# target environment on the build host system
+#   set 1st to dir with the cross compiler's C/C++ headers/libs
+set(CMAKE_FIND_ROOT_PATH "${CMAKE_CURRENT_SOURCE_DIR}/depends/${TOOLCHAIN_PREFIX};${OSX_SDK_PATH}")
+
+# We also may have built dependancies for the native plateform.
+set(CMAKE_PREFIX_PATH "${CMAKE_CURRENT_SOURCE_DIR}/depends/${TOOLCHAIN_PREFIX}/native")
+
+# modify default behavior of FIND_XXX() commands to
+# search for headers/libs in the target environment and
+# search for programs in the build host environment
+set(CMAKE_FIND_ROOT_PATH_MODE_PROGRAM NEVER)
+set(CMAKE_FIND_ROOT_PATH_MODE_LIBRARY ONLY)
+set(CMAKE_FIND_ROOT_PATH_MODE_INCLUDE ONLY)
+
+# Sysroot clang
+set(OSX_EXTRA_FLAGS
+	" -target ${TOOLCHAIN_PREFIX}"
+	" -mmacosx-version-min=10.8"
+	" --sysroot ${OSX_SDK_PATH}"
+	" -mlinker-version=253.9"
+)
+
+string(APPEND CMAKE_C_FLAGS ${OSX_EXTRA_FLAGS})
+string(APPEND CMAKE_CXX_FLAGS ${OSX_EXTRA_FLAGS} " -stdlib=libc++")
+
+# Ensure we use an OSX specific version of ar, ranlib and nm.
+find_program(CMAKE_AR ${TOOLCHAIN_PREFIX}-ar)
+find_program(CMAKE_RANLIB ${TOOLCHAIN_PREFIX}-ranlib)
+find_program(CMAKE_NM ${TOOLCHAIN_PREFIX}-nm)
diff --git a/depends/packages/native_cctools.mk b/depends/packages/native_cctools.mk
--- a/depends/packages/native_cctools.mk
+++ b/depends/packages/native_cctools.mk
@@ -21,7 +21,7 @@
   echo "$($(package)_sha256_hash)  $($(package)_source)" > $($(package)_extract_dir)/.$($(package)_file_name).hash && \
   echo "$($(package)_clang_sha256_hash)  $($(package)_source_dir)/$($(package)_clang_file_name)" >> $($(package)_extract_dir)/.$($(package)_file_name).hash && \
   $(build_SHA256SUM) -c $($(package)_extract_dir)/.$($(package)_file_name).hash && \
-  mkdir -p toolchain/bin toolchain/lib/clang/3.5/include && \
+  mkdir -p toolchain/bin && \
   tar --strip-components=1 -C toolchain -xf $($(package)_source_dir)/$($(package)_clang_file_name) && \
   rm -f toolchain/lib/libc++abi.so* && \
   echo "#!/bin/sh" > toolchain/bin/$(host)-dsymutil && \
diff --git a/src/qt/CMakeLists.txt b/src/qt/CMakeLists.txt
--- a/src/qt/CMakeLists.txt
+++ b/src/qt/CMakeLists.txt
@@ -122,6 +122,10 @@
 	${Protobuf_LIBRARIES}
 )
 
+if(${CMAKE_SYSTEM_NAME} MATCHES "Darwin")
+	set_property(TARGET bitcoin-qt-base PROPERTY AUTOMOC_MOC_OPTIONS "-DQ_OS_MAC")
+endif()
+
 # Wallet
 if(BUILD_BITCOIN_WALLET)
 	target_sources(bitcoin-qt-base
diff --git a/src/secp256k1/CMakeLists.txt b/src/secp256k1/CMakeLists.txt
--- a/src/secp256k1/CMakeLists.txt
+++ b/src/secp256k1/CMakeLists.txt
@@ -9,7 +9,7 @@
 	-Wshadow
 	-Wno-unused-function
 	-Wno-nonnull
-	-Wno-nonnull-compare
+	-Wno-overlength-strings
 )
 
 add_c_compiler_flag(