diff --git a/contrib/gitian-build.py b/contrib/gitian-build.py
--- a/contrib/gitian-build.py
+++ b/contrib/gitian-build.py
@@ -263,7 +263,7 @@
 
     # Disable for MacOS if no SDK found
     if args.macos and not os.path.isfile(
-            'gitian-builder/inputs/Xcode-11.3.1-11C505-extracted-SDK-with-libcxx-headers.tar.gz'):
+            'gitian-builder/inputs/Xcode-12.1-12A7403-extracted-SDK-with-libcxx-headers.tar.gz'):
         print('Cannot build for MacOS, SDK does not exist. Will build for other OSes')
         args.macos = False
 
diff --git a/contrib/gitian-descriptors/gitian-osx.yml b/contrib/gitian-descriptors/gitian-osx.yml
--- a/contrib/gitian-descriptors/gitian-osx.yml
+++ b/contrib/gitian-descriptors/gitian-osx.yml
@@ -36,7 +36,7 @@
 - "url": "https://github.com/Bitcoin-ABC/bitcoin-abc.git"
   "dir": "bitcoin"
 files:
-- "Xcode-11.3.1-11C505-extracted-SDK-with-libcxx-headers.tar.gz"
+- "Xcode-12.1-12A7403-extracted-SDK-with-libcxx-headers.tar.gz"
 script: |
   WRAP_DIR=$HOME/wrapped
   HOSTS=(
@@ -100,7 +100,7 @@
   BASEPREFIX=`pwd`/depends
 
   mkdir -p ${BASEPREFIX}/SDKs
-  tar -C ${BASEPREFIX}/SDKs -xf ${BUILD_DIR}/Xcode-11.3.1-11C505-extracted-SDK-with-libcxx-headers.tar.gz
+  tar -C ${BASEPREFIX}/SDKs -xf ${BUILD_DIR}/Xcode-12.1-12A7403-extracted-SDK-with-libcxx-headers.tar.gz
 
   # Build dependencies for each host
   for i in ${HOSTS[@]}; do
diff --git a/contrib/macdeploy/README.md b/contrib/macdeploy/README.md
--- a/contrib/macdeploy/README.md
+++ b/contrib/macdeploy/README.md
@@ -17,9 +17,9 @@
 ### Step 1: Obtaining `Xcode.app`
 
 Our current macOS SDK
-(`Xcode-11.3.1-11C505-extracted-SDK-with-libcxx-headers.tar.gz`) can be
+(`Xcode-12.1-12A7403-extracted-SDK-with-libcxx-headers.tar.gz`) can be
 extracted from
-[Xcode_11.3.1.xip](https://download.developer.apple.com/Developer_Tools/Xcode_11.3.1/Xcode_11.3.1.xip).
+[Xcode_12.1.xip](https://download.developer.apple.com/Developer_Tools/Xcode_12.1/Xcode_12.1.xip).
 An Apple ID is needed to download this.
 
 After Xcode version 7.x, Apple started shipping the `Xcode.app` in a `.xip`
@@ -30,25 +30,25 @@
 # Install/clone tools needed for extracting Xcode.app
 apt install cpio
 
-# Unpack Xcode_11.3.1.xip and place the resulting Xcode.app in your current
+# Unpack Xcode_12.1.xip and place the resulting Xcode.app in your current
 # working directory
-python3 contrib/apple-sdk-tools/extract_xcode.py -f Xcode_11.3.1.xip | cpio -d -i
+python3 contrib/apple-sdk-tools/extract_xcode.py -f Xcode_12.1.xip | cpio -d -i
 ```
 
 On macOS the process is more straightforward:
 
 ```bash
-xip -x Xcode_11.3.1.xip
+xip -x Xcode_12.1.xip
 ```
 
-### Step 2: Generating `Xcode-11.3.1-11C505-extracted-SDK-with-libcxx-headers.tar.gz` from `Xcode.app`
+### Step 2: Generating `Xcode-12.1-12A7403-extracted-SDK-with-libcxx-headers.tar.gz` from `Xcode.app`
 
-To generate `Xcode-11.3.1-11C505-extracted-SDK-with-libcxx-headers.tar.gz`, run
+To generate `Xcode-12.1-12A7403-extracted-SDK-with-libcxx-headers.tar.gz`, run
 the script [`gen-sdk`](./gen-sdk) with the path to `Xcode.app` (extracted in the
 previous stage) as the first argument.
 
 ```bash
-# Generate a Xcode-11.3.1-11C505-extracted-SDK-with-libcxx-headers.tar.gz from
+# Generate a Xcode-12.1-12A7403-extracted-SDK-with-libcxx-headers.tar.gz from
 # the supplied Xcode.app
 ./contrib/macdeploy/gen-sdk '/path/to/Xcode.app'
 ```
diff --git a/depends/hosts/darwin.mk b/depends/hosts/darwin.mk
--- a/depends/hosts/darwin.mk
+++ b/depends/hosts/darwin.mk
@@ -1,7 +1,7 @@
 OSX_MIN_VERSION=10.14
-OSX_SDK_VERSION=10.15.1
-XCODE_VERSION=11.3.1
-XCODE_BUILD_ID=11C505
+OSX_SDK_VERSION=10.15.6
+XCODE_VERSION=12.1
+XCODE_BUILD_ID=12A7403
 LD64_VERSION=609
 
 OSX_SDK=$(SDK_PATH)/Xcode-$(XCODE_VERSION)-$(XCODE_BUILD_ID)-extracted-SDK-with-libcxx-headers