diff --git a/src/qt/CMakeLists.txt b/src/qt/CMakeLists.txt
--- a/src/qt/CMakeLists.txt
+++ b/src/qt/CMakeLists.txt
@@ -262,14 +262,6 @@
 	find_brew_prefix(OPENSSL_ROOT_DIR openssl)
 	find_package(OpenSSL REQUIRED)
 
-	include(CheckSymbolExists)
-	set(CMAKE_REQUIRED_INCLUDES ${OPENSSL_INCLUDE_DIR})
-	set(CMAKE_REQUIRED_LIBRARIES ${OPENSSL_CRYPTO_LIBRARY})
-	check_symbol_exists(EVP_MD_CTX_new "openssl/evp.h" HAVE_DECL_EVP_MD_CTX_NEW)
-	if(HAVE_DECL_EVP_MD_CTX_NEW)
-		target_compile_definitions(bitcoin-qt-base PRIVATE HAVE_DECL_EVP_MD_CTX_NEW=1)
-	endif()
-
 	target_link_libraries(bitcoin-qt-base
 		OpenSSL::SSL
 		bitcoin-qt-protobuf
diff --git a/src/qt/paymentrequestplus.cpp b/src/qt/paymentrequestplus.cpp
--- a/src/qt/paymentrequestplus.cpp
+++ b/src/qt/paymentrequestplus.cpp
@@ -169,7 +169,7 @@
         std::string data_to_verify;
         rcopy.SerializeToString(&data_to_verify);
 
-#if HAVE_DECL_EVP_MD_CTX_NEW
+#if OPENSSL_VERSION_NUMBER >= 0x10100000L
         EVP_MD_CTX *ctx = EVP_MD_CTX_new();
         if (!ctx) {
             throw SSLVerifyError("Error allocating OpenSSL context.");
@@ -189,7 +189,7 @@
                 (unsigned int)paymentRequest.signature().size(), pubkey)) {
             throw SSLVerifyError("Bad signature, invalid payment request.");
         }
-#if HAVE_DECL_EVP_MD_CTX_NEW
+#if OPENSSL_VERSION_NUMBER >= 0x10100000L
         EVP_MD_CTX_free(ctx);
 #endif