diff --git a/contrib/devtools/security-check.py b/contrib/devtools/security-check.py
--- a/contrib/devtools/security-check.py
+++ b/contrib/devtools/security-check.py
@@ -118,7 +118,7 @@
         main, 4, lief.Binary.VA_TYPES.AUTO
     )
 
-    return content == [243, 15, 30, 250]  # endbr64
+    return content.tolist() == [243, 15, 30, 250]  # endbr64
 
 
 def check_PE_DYNAMIC_BASE(binary) -> bool:
@@ -159,7 +159,7 @@
         virtual_address, 4, lief.Binary.VA_TYPES.VA
     )
 
-    return content == [243, 15, 30, 250]  # endbr64
+    return content.tolist() == [243, 15, 30, 250]  # endbr64
 
 
 def check_MACHO_NOUNDEFS(binary) -> bool:
@@ -198,7 +198,7 @@
     content = binary.get_content_from_virtual_address(
         binary.entrypoint, 4, lief.Binary.VA_TYPES.AUTO
     )
-    return content == [243, 15, 30, 250]  # endbr64
+    return content.tolist() == [243, 15, 30, 250]  # endbr64
 
 
 BASE_ELF = [
diff --git a/contrib/gitian-descriptors/gitian-linux.yml b/contrib/gitian-descriptors/gitian-linux.yml
--- a/contrib/gitian-descriptors/gitian-linux.yml
+++ b/contrib/gitian-descriptors/gitian-linux.yml
@@ -119,7 +119,7 @@
   done
   }
 
-  pip3 install lief==0.11.5
+  pip3 install lief==0.13.2
 
   # Faketime for depends so intermediate results are comparable
   export PATH_orig=${PATH}
diff --git a/contrib/gitian-descriptors/gitian-osx.yml b/contrib/gitian-descriptors/gitian-osx.yml
--- a/contrib/gitian-descriptors/gitian-osx.yml
+++ b/contrib/gitian-descriptors/gitian-osx.yml
@@ -82,7 +82,7 @@
   done
   }
 
-  pip3 install lief==0.11.5
+  pip3 install lief==0.13.2
 
   # Faketime for depends so intermediate results are comparable
   export PATH_orig=${PATH}
diff --git a/contrib/gitian-descriptors/gitian-win.yml b/contrib/gitian-descriptors/gitian-win.yml
--- a/contrib/gitian-descriptors/gitian-win.yml
+++ b/contrib/gitian-descriptors/gitian-win.yml
@@ -93,7 +93,7 @@
   done
   }
 
-  pip3 install lief==0.11.5
+  pip3 install lief==0.13.2
 
   # Faketime for depends so intermediate results are comparable
   export PATH_orig=${PATH}
diff --git a/contrib/guix/manifest.scm b/contrib/guix/manifest.scm
--- a/contrib/guix/manifest.scm
+++ b/contrib/guix/manifest.scm
@@ -26,6 +26,7 @@
              (gnu packages perl)
              (gnu packages pkg-config)
              (gnu packages python)
+             ((gnu packages python-build) #:select (python-tomli))
              (gnu packages python-crypto)
              (gnu packages python-web)
              (gnu packages shells)
@@ -207,35 +208,50 @@
     (search-our-patches "nsis-gcc-10-memmove.patch"
                         "nsis-disable-installer-reloc.patch")))
 
-(define-public lief
+;; While LIEF is packaged in Guix, we maintain our own package,
+;; to simplify building, and more easily apply updates.
+;; Moreover, the Guix's package uses cmake, which caused build
+;; failure; see https://github.com/bitcoin/bitcoin/pull/27296.
+(define-public python-lief
   (package
-   (name "python-lief")
-   (version "0.12.1")
-   (source
-    (origin
-     (method git-fetch)
-     (uri (git-reference
-           (url "https://github.com/lief-project/LIEF.git")
-           (commit version)))
-     (file-name (git-file-name name version))
-     (sha256
-      (base32
-       "1xzbh3bxy4rw1yamnx68da1v5s56ay4g081cyamv67256g0qy2i1"))))
-   (build-system python-build-system)
-   (arguments
-    `(#:phases
-      (modify-phases %standard-phases
-        (add-after 'unpack 'parallel-jobs
-          ;; build with multiple cores
-          (lambda _
-            (substitute* "setup.py" (("self.parallel if self.parallel else 1") (number->string (parallel-job-count)))))))))
-   (native-inputs
-    `(("cmake" ,cmake)))
-   (home-page "https://github.com/lief-project/LIEF")
-   (synopsis "Library to Instrument Executable Formats")
-   (description "Python library to to provide a cross platform library which can
-parse, modify and abstract ELF, PE and MachO formats.")
-   (license license:asl2.0)))
+    (name "python-lief")
+    (version "0.13.2")
+    (source (origin
+              (method git-fetch)
+              (uri (git-reference
+                    (url "https://github.com/lief-project/LIEF")
+                    (commit version)))
+              (file-name (git-file-name name version))
+              (modules '((guix build utils)))
+              (snippet
+               '(begin
+                  ;; Configure build for Python bindings.
+                  (substitute* "api/python/config-default.toml"
+                    (("(ninja         = )true" all m)
+                     (string-append m "false"))
+                    (("(parallel-jobs = )0" all m)
+                     (string-append m (number->string (parallel-job-count)))))))
+              (sha256
+               (base32
+                "0y48x358ppig5xp97ahcphfipx7cg9chldj2q5zrmn610fmi4zll"))))
+    (build-system python-build-system)
+    (native-inputs (list cmake-minimal python-tomli))
+    (arguments
+     (list
+      #:tests? #f                  ;needs network
+      #:phases #~(modify-phases %standard-phases
+                   (add-before 'build 'change-directory
+                     (lambda _
+                       (chdir "api/python")))
+                   (replace 'build
+                     (lambda _
+                       (invoke "python" "setup.py" "build"))))))
+    (home-page "https://github.com/lief-project/LIEF")
+    (synopsis "Library to instrument executable formats")
+    (description
+     "@code{python-lief} is a cross platform library which can parse, modify
+and abstract ELF, PE and MachO formats.")
+    (license license:asl2.0)))
 
 (define osslsigncode
   (package
@@ -598,7 +614,7 @@
         ;; Git
         git-minimal
         ;; Tests
-        lief)
+        python-lief)
   (let ((target (getenv "HOST")))
     (cond ((string-suffix? "-mingw32" target)
            ;; Windows
diff --git a/contrib/utils/install-dependencies-bullseye.sh b/contrib/utils/install-dependencies-bullseye.sh
--- a/contrib/utils/install-dependencies-bullseye.sh
+++ b/contrib/utils/install-dependencies-bullseye.sh
@@ -147,7 +147,7 @@
 # This version is compatible with Debian's "protobuf-compiler" package
 pip3 install "protobuf<=3.20"
 # For security-check.py and symbol-check.py
-pip3 install "lief>=0.11.5"
+pip3 install "lief>=0.13.2"
 # For Chronik WebSocket endpoint
 pip3 install websocket-client