diff --git a/test/functional/mempool_expiry.py b/test/functional/mempool_expiry.py
--- a/test/functional/mempool_expiry.py
+++ b/test/functional/mempool_expiry.py
@@ -22,18 +22,11 @@
 class MempoolExpiryTest(BitcoinTestFramework):
     def set_test_params(self):
         self.num_nodes = 1
-        self.setup_clean_chain = True
 
     def test_transaction_expiry(self, timeout):
         """Tests that a transaction expires after the expiry timeout and its
         children are removed as well."""
         node = self.nodes[0]
-        self.wallet = MiniWallet(node)
-
-        # Add enough mature utxos to the wallet so that all txs spend confirmed
-        # coins.
-        self.generate(self.wallet, 4)
-        self.generate(node, 100)
 
         # Send a parent transaction that will expire.
         parent_txid = self.wallet.send_self_transfer(from_node=node)["txid"]
@@ -110,6 +103,8 @@
         assert_equal(half_expiry_time, node.getmempoolentry(independent_txid)["time"])
 
     def run_test(self):
+        self.wallet = MiniWallet(self.nodes[0])
+
         self.log.info(
             f"Test default mempool expiry timeout of {DEFAULT_MEMPOOL_EXPIRY_HOURS} hours."
         )
diff --git a/test/functional/mempool_resurrect.py b/test/functional/mempool_resurrect.py
--- a/test/functional/mempool_resurrect.py
+++ b/test/functional/mempool_resurrect.py
@@ -11,17 +11,11 @@
 class MempoolCoinbaseTest(BitcoinTestFramework):
     def set_test_params(self):
         self.num_nodes = 1
-        self.setup_clean_chain = True
 
     def run_test(self):
         node = self.nodes[0]
         wallet = MiniWallet(node)
 
-        # Add enough mature utxos to the wallet so that all txs spend confirmed
-        # coins
-        self.generate(wallet, 3)
-        self.generate(node, 100)
-
         # Spend block 1/2/3's coinbase transactions
         # Mine a block
         # Create three more transactions, spending the spends
diff --git a/test/functional/rpc_net.py b/test/functional/rpc_net.py
--- a/test/functional/rpc_net.py
+++ b/test/functional/rpc_net.py
@@ -43,7 +43,6 @@
 
 class NetTest(BitcoinTestFramework):
     def set_test_params(self):
-        self.setup_clean_chain = True
         self.num_nodes = 2
         self.extra_args = [
             [
@@ -60,8 +59,6 @@
         self.supports_cli = False
 
     def run_test(self):
-        # Get out of IBD for the minfeefilter and getpeerinfo tests.
-        self.generate(self.nodes[0], 101)
         # Connect nodes both ways.
         self.connect_nodes(0, 1)
         self.connect_nodes(1, 0)
diff --git a/test/functional/rpc_rawtransaction.py b/test/functional/rpc_rawtransaction.py
--- a/test/functional/rpc_rawtransaction.py
+++ b/test/functional/rpc_rawtransaction.py
@@ -46,7 +46,6 @@
 # Create one-input, one-output, no-fee transaction:
 class RawTransactionsTest(BitcoinTestFramework):
     def set_test_params(self):
-        self.setup_clean_chain = True
         self.num_nodes = 3
         self.extra_args = [["-txindex"], ["-txindex"], ["-txindex"]]
         # whitelist all peers to speed up tx relay / mempool sync
@@ -63,15 +62,6 @@
         self.connect_nodes(0, 2)
 
     def run_test(self):
-        self.log.info("prepare some coins for multiple *rawtransaction commands")
-        self.generate(self.nodes[2], 1)
-        self.generate(self.nodes[0], 101)
-        self.nodes[0].sendtoaddress(self.nodes[2].getnewaddress(), 1500000)
-        self.nodes[0].sendtoaddress(self.nodes[2].getnewaddress(), 1000000)
-        self.nodes[0].sendtoaddress(self.nodes[2].getnewaddress(), 5000000)
-        self.sync_all()
-        self.generate(self.nodes[0], 5)
-
         self.log.info(
             "Test getrawtransaction on genesis block coinbase returns an error"
         )
diff --git a/test/functional/rpc_txoutproof.py b/test/functional/rpc_txoutproof.py
--- a/test/functional/rpc_txoutproof.py
+++ b/test/functional/rpc_txoutproof.py
@@ -12,7 +12,6 @@
 class MerkleBlockTest(BitcoinTestFramework):
     def set_test_params(self):
         self.num_nodes = 2
-        self.setup_clean_chain = True
         self.extra_args = [
             [],
             ["-txindex"],
@@ -20,13 +19,9 @@
 
     def run_test(self):
         miniwallet = MiniWallet(self.nodes[0])
-        # Add enough mature utxos to the wallet, so that all txs spend
-        # confirmed coins
-        self.generate(miniwallet, 5)
-        self.generate(self.nodes[0], 100)
 
         chain_height = self.nodes[1].getblockcount()
-        assert_equal(chain_height, 105)
+        assert_equal(chain_height, 200)
 
         txid1 = miniwallet.send_self_transfer(from_node=self.nodes[0])["txid"]
         txid2 = miniwallet.send_self_transfer(from_node=self.nodes[0])["txid"]