diff --git a/test/functional/test_runner.py b/test/functional/test_runner.py
--- a/test/functional/test_runner.py
+++ b/test/functional/test_runner.py
@@ -75,7 +75,8 @@
     #    testName --param1 --param2
     #    testname --param3
     "txn_doublespend.py": [["--mineblock"]],
-    "txn_clone.py": [["--mineblock"]]
+    "txn_clone.py": [["--mineblock"]],
+    "wallet_multiwallet.py": [["--usecli"]]
 }
 
 # Used to limit the number of tests, when list of tests is not provided on command line
diff --git a/test/functional/wallet_multiwallet.py b/test/functional/wallet_multiwallet.py
--- a/test/functional/wallet_multiwallet.py
+++ b/test/functional/wallet_multiwallet.py
@@ -19,9 +19,18 @@
         self.num_nodes = 1
         self.extra_args = [
             ['-wallet=w1', '-wallet=w2', '-wallet=w3', '-wallet=w']]
+        self.supports_cli = True
 
     def run_test(self):
-        assert_equal(set(self.nodes[0].listwallets()), {"w1", "w2", "w3", "w"})
+        node = self.nodes[0]
+
+        data_dir = lambda *p: os.path.join(node.datadir, 'regtest', *p)
+        wallet_dir = lambda *p: data_dir('wallets', *p)
+
+        def wallet(name): return node.get_wallet_rpc(name)
+
+        assert_equal(set(node.listwallets()), {"w1", "w2", "w3", "w"})
+
         self.stop_node(0)
 
         # should not initialize if there are duplicate wallets
@@ -29,21 +38,17 @@
             0, ['-wallet=w1', '-wallet=w1'], 'Error loading wallet w1. Duplicate -wallet filename specified.')
 
         # should not initialize if wallet file is a directory
-        wallet_dir = os.path.join(
-            self.options.tmpdir, 'node0', 'regtest', 'wallets')
-        os.mkdir(os.path.join(wallet_dir, 'w11'))
+        os.mkdir(wallet_dir('w11'))
         self.assert_start_raises_init_error(
             0, ['-wallet=w11'], 'Error loading wallet w11. -wallet filename must be a regular file.')
 
         # should not initialize if one wallet is a copy of another
-        shutil.copyfile(os.path.join(wallet_dir, 'w2'),
-                        os.path.join(wallet_dir, 'w22'))
+        shutil.copyfile(wallet_dir('w2'), wallet_dir('w22'))
         self.assert_start_raises_init_error(
             0, ['-wallet=w2', '-wallet=w22'], 'duplicates fileid')
 
         # should not initialize if wallet file is a symlink
-        os.symlink(os.path.join(wallet_dir, 'w1'),
-                   os.path.join(wallet_dir, 'w12'))
+        os.symlink(wallet_dir('w1'), wallet_dir('w12'))
         self.assert_start_raises_init_error(
             0, ['-wallet=w12'], 'Error loading wallet w12. -wallet filename must be a regular file.')
 
@@ -51,27 +56,26 @@
         self.assert_start_raises_init_error(
             0, ['-walletdir=bad'], 'Error: Specified -walletdir "bad" does not exist')
         # should not initialize if the specified walletdir is not a directory
-        not_a_dir = os.path.join(wallet_dir, 'notadir')
+        not_a_dir = wallet_dir('notadir')
         open(not_a_dir, 'a').close()
         self.assert_start_raises_init_error(
             0, ['-walletdir='+not_a_dir], 'Error: Specified -walletdir "' + not_a_dir + '" is not a directory')
 
         # if wallets/ doesn't exist, datadir should be the default wallet dir
-        wallet_dir2 = os.path.join(
-            self.options.tmpdir, 'node0', 'regtest', 'walletdir')
-        os.rename(wallet_dir, wallet_dir2)
+        wallet_dir2 = data_dir('walletdir')
+        os.rename(wallet_dir(), wallet_dir2)
         self.start_node(0, ['-wallet=w4', '-wallet=w5'])
-        assert_equal(set(self.nodes[0].listwallets()), {"w4", "w5"})
-        w5 = self.nodes[0].get_wallet_rpc("w5")
+        assert_equal(set(node.listwallets()), {"w4", "w5"})
+        w5 = wallet("w5")
         w5.generate(1)
         self.stop_node(0)
 
         # now if wallets/ exists again, but the rootdir is specified as the walletdir, w4 and w5 should still be loaded
-        os.rename(wallet_dir2, wallet_dir)
-        self.start_node(0, ['-wallet=w4', '-wallet=w5', '-walletdir=' +
-                            os.path.join(self.options.tmpdir, 'node0', 'regtest')])
-        assert_equal(set(self.nodes[0].listwallets()), {"w4", "w5"})
-        w5 = self.nodes[0].get_wallet_rpc("w5")
+        os.rename(wallet_dir2, wallet_dir())
+        self.start_node(0, ['-wallet=w4', '-wallet=w5',
+                            '-walletdir=' + data_dir()])
+        assert_equal(set(node.listwallets()), {"w4", "w5"})
+        w5 = wallet("w5")
         w5_info = w5.getwalletinfo()
         assert_equal(w5_info['immature_balance'], 50)
 
@@ -79,11 +83,11 @@
 
         self.start_node(0, self.extra_args[0])
 
-        w1 = self.nodes[0].get_wallet_rpc("w1")
-        w2 = self.nodes[0].get_wallet_rpc("w2")
-        w3 = self.nodes[0].get_wallet_rpc("w3")
-        w4 = self.nodes[0].get_wallet_rpc("w")
-        wallet_bad = self.nodes[0].get_wallet_rpc("bad")
+        w1 = wallet("w1")
+        w2 = wallet("w2")
+        w3 = wallet("w3")
+        w4 = wallet("w")
+        wallet_bad = wallet("bad")
 
         w1.generate(1)
 
@@ -93,7 +97,7 @@
 
         # accessing wallet RPC without using wallet endpoint fails
         assert_raises_rpc_error(-19, "Wallet file not specified (must request wallet RPC through /wallet/<filename> uri-path).",
-                                self.nodes[0].getwalletinfo)
+                                node.getwalletinfo)
 
         # check w1 wallet balance
         w1_info = w1.getwalletinfo()