diff --git a/src/validation.cpp b/src/validation.cpp
--- a/src/validation.cpp
+++ b/src/validation.cpp
@@ -4297,6 +4297,16 @@
     int count = 0;
 
     if (nCurrentUsage + nBuffer >= nPruneTarget) {
+        // On a prune event, the chainstate DB is flushed.
+        // To avoid excessive prune events negating the benefit of high dbcache
+        // values, we should not prune too rapidly.
+        // So when pruning in IBD, increase the buffer a bit to avoid a re-prune
+        // too soon.
+        if (IsInitialBlockDownload()) {
+            // Since this is only relevant during IBD, we use a fixed 10%
+            nBuffer += nPruneTarget / 10;
+        }
+
         for (int fileNumber = 0; fileNumber < nLastBlockFile; fileNumber++) {
             nBytesToPrune = vinfoBlockFile[fileNumber].nSize +
                             vinfoBlockFile[fileNumber].nUndoSize;