diff --git a/CMakeLists.txt b/CMakeLists.txt
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -30,9 +30,10 @@
 		"Select the configuration for the build" FORCE)
 endif()
 
-# Add the magic targets `check` and `check-all`
+# Add the magic targets `check`, `check-all` and `check-symbols`
 add_custom_target(check-all)
 add_custom_target(check)
+add_custom_target(check-symbols)
 
 add_subdirectory(src)
 add_subdirectory(test)
diff --git a/cmake/modules/BinaryTest.cmake b/cmake/modules/BinaryTest.cmake
new file mode 100644
--- /dev/null
+++ b/cmake/modules/BinaryTest.cmake
@@ -0,0 +1,18 @@
+# Facilities to run tests on the executable binaries.
+
+macro(add_to_symbols_check BINARY)
+	set(CUSTOM_TARGET_NAME "check-symbols-${BINARY}")
+	add_custom_target("${CUSTOM_TARGET_NAME}"
+		COMMAND
+			${CMAKE_COMMAND} -E echo "Running symbol-check.py on ${BINARY}..."
+		COMMAND
+			"${CMAKE_SOURCE_DIR}/contrib/devtools/symbol-check.py"
+			"${BINARY}"
+		DEPENDS
+			"${BINARY}"
+	)
+
+	if(TARGET check-symbols)
+		add_dependencies(check-symbols "${CUSTOM_TARGET_NAME}")
+	endif()
+endmacro()
diff --git a/src/CMakeLists.txt b/src/CMakeLists.txt
--- a/src/CMakeLists.txt
+++ b/src/CMakeLists.txt
@@ -448,6 +448,8 @@
 	add_subdirectory(seeder)
 endif()
 
+include(BinaryTest)
+
 # bitcoin-cli
 if(BUILD_BITCOIN_CLI)
 	add_executable(bitcoin-cli bitcoin-cli.cpp)
@@ -456,6 +458,8 @@
 	endif()
 
 	target_link_libraries(bitcoin-cli common rpcclient Event)
+
+	add_to_symbols_check(bitcoin-cli)
 endif()
 
 # bitcoin-tx
@@ -466,6 +470,8 @@
 	endif()
 
 	target_link_libraries(bitcoin-tx bitcoinconsensus)
+
+	add_to_symbols_check(bitcoin-tx)
 endif()
 
 # bitcoind
@@ -474,6 +480,7 @@
 if(${CMAKE_SYSTEM_NAME} MATCHES "Windows")
 	target_sources(bitcoind PRIVATE bitcoind-res.rc)
 endif()
+add_to_symbols_check(bitcoind)
 
 # Bitcoin-qt
 if(BUILD_BITCOIN_QT)
diff --git a/src/bench/CMakeLists.txt b/src/bench/CMakeLists.txt
--- a/src/bench/CMakeLists.txt
+++ b/src/bench/CMakeLists.txt
@@ -69,3 +69,6 @@
 	DEPENDS
 		bitcoin-bench
 )
+
+include(BinaryTest)
+add_to_symbols_check(bitcoin-bench)
diff --git a/src/qt/CMakeLists.txt b/src/qt/CMakeLists.txt
--- a/src/qt/CMakeLists.txt
+++ b/src/qt/CMakeLists.txt
@@ -279,5 +279,8 @@
 add_executable(bitcoin-qt WIN32 bitcoin.cpp)
 target_link_libraries(bitcoin-qt bitcoin-qt-base)
 
+include(BinaryTest)
+add_to_symbols_check(bitcoin-qt)
+
 # Test tests
 add_subdirectory(test)
diff --git a/src/qt/test/CMakeLists.txt b/src/qt/test/CMakeLists.txt
--- a/src/qt/test/CMakeLists.txt
+++ b/src/qt/test/CMakeLists.txt
@@ -34,3 +34,6 @@
 
 	target_link_libraries(test_bitcoin-qt wallet)
 endif()
+
+include(BinaryTest)
+add_to_symbols_check(test_bitcoin-qt)
diff --git a/src/seeder/CMakeLists.txt b/src/seeder/CMakeLists.txt
--- a/src/seeder/CMakeLists.txt
+++ b/src/seeder/CMakeLists.txt
@@ -12,3 +12,6 @@
 )
 
 target_link_libraries(bitcoin-seeder common)
+
+include(BinaryTest)
+add_to_symbols_check(bitcoin-seeder)
diff --git a/src/test/CMakeLists.txt b/src/test/CMakeLists.txt
--- a/src/test/CMakeLists.txt
+++ b/src/test/CMakeLists.txt
@@ -179,3 +179,6 @@
 			../wallet/test/coinselector_tests.cpp
 	)
 endif()
+
+include(BinaryTest)
+add_to_symbols_check(test_bitcoin)