diff --git a/CMakeLists.txt b/CMakeLists.txt
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -30,10 +30,12 @@
 		"Select the configuration for the build" FORCE)
 endif()
 
-# Add the magic targets `check`, `check-all` and `check-symbols`
+# Add the magic targets `check`, `check-all`, `check-symbols` and
+# `check-security`
 add_custom_target(check-all)
 add_custom_target(check)
 add_custom_target(check-symbols)
+add_custom_target(check-security)
 
 add_subdirectory(src)
 add_subdirectory(test)
diff --git a/cmake/modules/BinaryTest.cmake b/cmake/modules/BinaryTest.cmake
--- a/cmake/modules/BinaryTest.cmake
+++ b/cmake/modules/BinaryTest.cmake
@@ -16,3 +16,20 @@
 		add_dependencies(check-symbols "${CUSTOM_TARGET_NAME}")
 	endif()
 endmacro()
+
+macro(add_to_security_check BINARY)
+	set(CUSTOM_TARGET_NAME "check-security-${BINARY}")
+	add_custom_target("${CUSTOM_TARGET_NAME}"
+		COMMAND
+			${CMAKE_COMMAND} -E echo "Running security-check.py on ${BINARY}..."
+		COMMAND
+			"${CMAKE_SOURCE_DIR}/contrib/devtools/security-check.py"
+			"${BINARY}"
+		DEPENDS
+			"${BINARY}"
+	)
+
+	if(TARGET check-security)
+		add_dependencies(check-security "${CUSTOM_TARGET_NAME}")
+	endif()
+endmacro()
diff --git a/src/CMakeLists.txt b/src/CMakeLists.txt
--- a/src/CMakeLists.txt
+++ b/src/CMakeLists.txt
@@ -460,6 +460,7 @@
 	target_link_libraries(bitcoin-cli common rpcclient Event)
 
 	add_to_symbols_check(bitcoin-cli)
+	add_to_security_check(bitcoin-cli)
 endif()
 
 # bitcoin-tx
@@ -472,6 +473,7 @@
 	target_link_libraries(bitcoin-tx bitcoinconsensus)
 
 	add_to_symbols_check(bitcoin-tx)
+	add_to_security_check(bitcoin-tx)
 endif()
 
 # bitcoind
@@ -481,6 +483,7 @@
 	target_sources(bitcoind PRIVATE bitcoind-res.rc)
 endif()
 add_to_symbols_check(bitcoind)
+add_to_security_check(bitcoind)
 
 # Bitcoin-qt
 if(BUILD_BITCOIN_QT)
diff --git a/src/bench/CMakeLists.txt b/src/bench/CMakeLists.txt
--- a/src/bench/CMakeLists.txt
+++ b/src/bench/CMakeLists.txt
@@ -72,3 +72,4 @@
 
 include(BinaryTest)
 add_to_symbols_check(bitcoin-bench)
+add_to_security_check(bitcoin-bench)
diff --git a/src/qt/CMakeLists.txt b/src/qt/CMakeLists.txt
--- a/src/qt/CMakeLists.txt
+++ b/src/qt/CMakeLists.txt
@@ -281,6 +281,7 @@
 
 include(BinaryTest)
 add_to_symbols_check(bitcoin-qt)
+add_to_security_check(bitcoin-qt)
 
 # Test tests
 add_subdirectory(test)
diff --git a/src/qt/test/CMakeLists.txt b/src/qt/test/CMakeLists.txt
--- a/src/qt/test/CMakeLists.txt
+++ b/src/qt/test/CMakeLists.txt
@@ -37,3 +37,4 @@
 
 include(BinaryTest)
 add_to_symbols_check(test_bitcoin-qt)
+add_to_security_check(test_bitcoin-qt)
diff --git a/src/seeder/CMakeLists.txt b/src/seeder/CMakeLists.txt
--- a/src/seeder/CMakeLists.txt
+++ b/src/seeder/CMakeLists.txt
@@ -15,3 +15,4 @@
 
 include(BinaryTest)
 add_to_symbols_check(bitcoin-seeder)
+add_to_security_check(bitcoin-seeder)
diff --git a/src/test/CMakeLists.txt b/src/test/CMakeLists.txt
--- a/src/test/CMakeLists.txt
+++ b/src/test/CMakeLists.txt
@@ -182,3 +182,4 @@
 
 include(BinaryTest)
 add_to_symbols_check(test_bitcoin)
+add_to_security_check(test_bitcoin)