diff --git a/configure.ac b/configure.ac
--- a/configure.ac
+++ b/configure.ac
@@ -617,13 +617,13 @@
 dnl Check for pthread compile/link requirements
 AX_PTHREAD
 
-# Check for off_t vs off64_t before AC_SYS_LARGEFILE gets called as it will
-# change the output
-AC_MSG_CHECKING(for if type off_t equals off64_t)
+# Check for Large File Supprot before AC_SYS_LARGEFILE gets called as it will
+# change the output.
+AC_MSG_CHECKING(for if LFS is enabled)
 AC_COMPILE_IFELSE([AC_LANG_PROGRAM([[#include <sys/types.h>
   #include <type_traits>]],
- [[ static_assert(std::is_same<off_t, off64_t>::value, ""); ]])],
- [ AC_MSG_RESULT(yes); need_wrap_fcntl=no; AC_DEFINE(OFF_T_EQUALS_OFF64_T, 1,[Define this symbol if type off_t equals off64_t]) ],
+ [[ static_assert(sizeof(off_t) == 8, ""); ]])],
+ [ AC_MSG_RESULT(yes); need_wrap_fcntl=no; AC_DEFINE(HAVE_LARGE_FILE_SUPPORT, 1,[Define this symbol if LFS is enabled]) ],
  [ AC_MSG_RESULT(no); need_wrap_fcntl=yes]
 )
 
diff --git a/src/CMakeLists.txt b/src/CMakeLists.txt
--- a/src/CMakeLists.txt
+++ b/src/CMakeLists.txt
@@ -298,13 +298,19 @@
 	add_linker_flags(-Wl,--wrap=__divmoddi4)
 	add_linker_flags(-Wl,--wrap=log2f)
 
-	if(NOT OFF_T_EQUALS_OFF64_T)
+	if(NOT HAVE_LARGE_FILE_SUPPORT)
 		add_linker_flags(-Wl,--wrap=fcntl -Wl,--wrap=fcntl64)
 	endif()
 
 	target_sources(util PRIVATE compat/glibc_compat.cpp)
 endif()
 
+# Enable LFS (Large File Support) on targets that don't have it natively.
+if(NOT HAVE_LARGE_FILE_SUPPORT)
+	add_compiler_flags(-D_FILE_OFFSET_BITS=64)
+	add_linker_flags(-Wl,--large-address-aware)
+endif()
+
 # Target specific configs
 if(${CMAKE_SYSTEM_NAME} MATCHES "Windows")
 	set(Boost_USE_STATIC_LIBS ON)
diff --git a/src/compat/glibc_compat.cpp b/src/compat/glibc_compat.cpp
--- a/src/compat/glibc_compat.cpp
+++ b/src/compat/glibc_compat.cpp
@@ -83,7 +83,7 @@
  * compatibility symbol for these architectures. We can link the new `fcntl()`
  * and `fcntl64()` against this symbol with the help of a wrapper.
  */
-#if defined(HAVE_CONFIG_H) && !defined(OFF_T_EQUALS_OFF64_T)
+#if defined(HAVE_CONFIG_H) && !defined(HAVE_LARGE_FILE_SUPPORT)
 extern "C" int fcntl_old(int fd, int cmd, ...);
 #ifdef __i386__
 __asm(".symver fcntl_old,fcntl@GLIBC_2.0");
diff --git a/src/config/CMakeLists.txt b/src/config/CMakeLists.txt
--- a/src/config/CMakeLists.txt
+++ b/src/config/CMakeLists.txt
@@ -162,10 +162,10 @@
     #include <sys/types.h>
     #include <type_traits>
     int main() {
-        static_assert(std::is_same<off_t, off64_t>::value, \"\");
+        static_assert(sizeof(off_t) == 8, \"\");
         return 0;
     }
-" OFF_T_EQUALS_OFF64_T)
+" HAVE_LARGE_FILE_SUPPORT)
 
 check_cxx_source_compiles("
     __attribute__((visibility(\"default\"))) int main() {
diff --git a/src/config/bitcoin-config.h.cmake.in b/src/config/bitcoin-config.h.cmake.in
--- a/src/config/bitcoin-config.h.cmake.in
+++ b/src/config/bitcoin-config.h.cmake.in
@@ -53,7 +53,7 @@
 #cmakedefine HAVE_SYSCTL_ARND 1
 
 #cmakedefine CHAR_EQUALS_INT8 0
-#cmakedefine OFF_T_EQUALS_OFF64_T 1
+#cmakedefine HAVE_LARGE_FILE_SUPPORT 1
 
 #cmakedefine HAVE_FUNC_ATTRIBUTE_VISIBILITY 1
 #cmakedefine HAVE_FUNC_ATTRIBUTE_DLLEXPORT 1