diff --git a/src/qt/CMakeLists.txt b/src/qt/CMakeLists.txt
--- a/src/qt/CMakeLists.txt
+++ b/src/qt/CMakeLists.txt
@@ -341,6 +341,14 @@
 			MACOSX_PACKAGE_LOCATION "Resources/${INFO_PLIST_STRINGS_FILE}"
 	)
 
+	# Always strip the application bundle binary.
+	# Note that the arguments to the `strip` command are OSX specific.
+	add_custom_command(
+		TARGET BitcoinABC-Qt
+		POST_BUILD
+		COMMAND "${CMAKE_STRIP}" -u -r "$<TARGET_FILE:BitcoinABC-Qt>"
+	)
+
 	include(DoOrFail)
 	find_program_or_fail(CMAKE_INSTALL_NAME_TOOL "install_name_tool")
 	find_program_or_fail(CMAKE_OTOOL "otool")