diff --git a/cmake/platforms/OSX.cmake b/cmake/platforms/OSX.cmake
--- a/cmake/platforms/OSX.cmake
+++ b/cmake/platforms/OSX.cmake
@@ -2,7 +2,7 @@
 
 set(CMAKE_SYSTEM_NAME Darwin)
 set(CMAKE_SYSTEM_PROCESSOR x86_64)
-set(TOOLCHAIN_PREFIX ${CMAKE_SYSTEM_PROCESSOR}-apple-darwin14)
+set(TOOLCHAIN_PREFIX ${CMAKE_SYSTEM_PROCESSOR}-apple-darwin16)
 
 # On OSX, we use clang by default.
 set(CMAKE_C_COMPILER clang)
@@ -14,7 +14,7 @@
 # On OSX we use various stuff from Apple's SDK.
 set(OSX_SDK_PATH "${CMAKE_CURRENT_SOURCE_DIR}/depends/SDKs/MacOSX10.11.sdk")
 set(CMAKE_OSX_SYSROOT ${OSX_SDK_PATH})
-set(CMAKE_OSX_DEPLOYMENT_TARGET 10.10)
+set(CMAKE_OSX_DEPLOYMENT_TARGET 10.12)
 set(CMAKE_OSX_ARCHITECTURES x86_64)
 
 # target environment on the build host system
diff --git a/contrib/gitian-descriptors/gitian-osx.yml b/contrib/gitian-descriptors/gitian-osx.yml
--- a/contrib/gitian-descriptors/gitian-osx.yml
+++ b/contrib/gitian-descriptors/gitian-osx.yml
@@ -43,7 +43,7 @@
 - "MacOSX10.11.sdk.tar.gz"
 script: |
   WRAP_DIR=$HOME/wrapped
-  HOSTS="x86_64-apple-darwin14"
+  HOSTS="x86_64-apple-darwin16"
 
   # CMake toolchain file name differ from host name
   declare -A CMAKE_TOOLCHAIN_FILE
diff --git a/depends/Makefile b/depends/Makefile
--- a/depends/Makefile
+++ b/depends/Makefile
@@ -178,7 +178,7 @@
 download-one: check-sources $(all_sources)
 
 download-osx:
-	@$(MAKE) -s HOST=x86_64-apple-darwin14 download-one
+	@$(MAKE) -s HOST=x86_64-apple-darwin16 download-one
 download-linux:
 	@$(MAKE) -s HOST=x86_64-unknown-linux-gnu download-one
 download-win:
@@ -194,7 +194,7 @@
 build-linux-aarch64: download-linux
 	@$(MAKE) -s HOST=aarch64-linux-gnu install
 build-osx: download-osx
-	@$(MAKE) -s HOST=x86_64-apple-darwin14 install
+	@$(MAKE) -s HOST=x86_64-apple-darwin16 install
 build-win32: download-win
 	@$(MAKE) -s HOST=i686-w64-mingw32 install
 build-win64: download-win
diff --git a/depends/hosts/darwin.mk b/depends/hosts/darwin.mk
--- a/depends/hosts/darwin.mk
+++ b/depends/hosts/darwin.mk
@@ -1,4 +1,4 @@
-OSX_MIN_VERSION=10.10
+OSX_MIN_VERSION=10.12
 OSX_SDK_VERSION=10.11
 OSX_SDK=$(SDK_PATH)/MacOSX$(OSX_SDK_VERSION).sdk
 LD64_VERSION=253.9
diff --git a/doc/release-notes.md b/doc/release-notes.md
--- a/doc/release-notes.md
+++ b/doc/release-notes.md
@@ -5,6 +5,9 @@
 This release includes the following features and fixes:
  - Fixed a bug where the `listtransactions` RPC was unable to list transactions
    by a giving label.  This functionality has been restored.
+ - MacOS versions earlier than 10.12 are no longer supported.
+   Additionally, Bitcoin ABC does not yet change appearance when macOS
+   "dark mode" is activated.
 
 Low-level RPC changes
 ----------------------
diff --git a/share/qt/Info.plist.in b/share/qt/Info.plist.in
--- a/share/qt/Info.plist.in
+++ b/share/qt/Info.plist.in
@@ -3,7 +3,7 @@
 <plist version="0.9">
 <dict>
   <key>LSMinimumSystemVersion</key>
-  <string>10.10.0</string>
+  <string>10.12.0</string>
 
   <key>LSArchitecturePriority</key>
   <array>