diff --git a/src/CMakeLists.txt b/src/CMakeLists.txt
--- a/src/CMakeLists.txt
+++ b/src/CMakeLists.txt
@@ -207,6 +207,14 @@
 	)
 endif()
 
+# Enable LFS (Large File Support) on targets that don't have it natively.
+# This should be defined before the libraries are included as leveldb need the
+# definition to be set.
+if(NOT HAVE_LARGE_FILE_SUPPORT)
+	add_compile_definitions(_FILE_OFFSET_BITS=64)
+	add_linker_flags(-Wl,--large-address-aware)
+endif()
+
 # Create a target for OpenSSL
 include(BrewHelper)
 find_brew_prefix(OPENSSL_ROOT_DIR openssl)
@@ -331,12 +339,6 @@
 	target_sources(util PRIVATE compat/glibc_compat.cpp)
 endif()
 
-# Enable LFS (Large File Support) on targets that don't have it natively.
-if(NOT HAVE_LARGE_FILE_SUPPORT)
-	add_compiler_flags(-D_FILE_OFFSET_BITS=64)
-	add_linker_flags(-Wl,--large-address-aware)
-endif()
-
 # Target specific configs
 if(${CMAKE_SYSTEM_NAME} MATCHES "Windows")
 	set(Boost_USE_STATIC_LIBS ON)