diff --git a/src/qt/bitcoingui.cpp b/src/qt/bitcoingui.cpp
--- a/src/qt/bitcoingui.cpp
+++ b/src/qt/bitcoingui.cpp
@@ -446,12 +446,23 @@
                 &BitcoinGUI::openClicked);
         connect(m_open_wallet_action->menu(), &QMenu::aboutToShow, [this] {
             m_open_wallet_action->menu()->clear();
-            for (std::string path :
-                 m_wallet_controller->getWalletsAvailableToOpen()) {
+            std::vector<std::string> available_wallets =
+                m_wallet_controller->getWalletsAvailableToOpen();
+            std::vector<std::string> wallets = m_node.listWalletDir();
+            for (const auto &path : wallets) {
                 QString name = path.empty()
                                    ? QString("[" + tr("default wallet") + "]")
                                    : QString::fromStdString(path);
                 QAction *action = m_open_wallet_action->menu()->addAction(name);
+
+                if (std::find(available_wallets.begin(),
+                              available_wallets.end(),
+                              path) == available_wallets.end()) {
+                    // This wallet is already loaded
+                    action->setEnabled(false);
+                    continue;
+                }
+
                 connect(action, &QAction::triggered, [this, name, path] {
                     OpenWalletActivity *activity =
                         m_wallet_controller->openWallet(
@@ -485,6 +496,11 @@
                             &QObject::deleteLater);
                 });
             }
+            if (wallets.empty()) {
+                QAction *action = m_open_wallet_action->menu()->addAction(
+                    tr("No wallets available"));
+                action->setEnabled(false);
+            }
         });
     }
 #endif // ENABLE_WALLET