diff --git a/src/config/CMakeLists.txt b/src/config/CMakeLists.txt
--- a/src/config/CMakeLists.txt
+++ b/src/config/CMakeLists.txt
@@ -6,6 +6,7 @@
 include(CheckIncludeFiles)
 include(CheckSymbolExists)
 include(CheckCXXSourceCompiles)
+include(SanitizeHelper)
 
 # Version
 set(CLIENT_VERSION_MAJOR ${bitcoin-abc_VERSION_MAJOR})
@@ -17,9 +18,25 @@
 # Generate the version.h file
 configure_file(version.h.cmake.in version.h ESCAPE_QUOTES)
 
+# Wrapper for the check_include_files() macro.
+# The find_path() function honors the sysroot variables, and will help
+# us adding the correct include path for check_include_files().
+# The most obvious use case is to help finding header files located in
+# an Apple Framework.
+function(check_include_files_with_sysroot INCLUDES)
+	foreach(INCLUDE ${INCLUDES})
+		sanitize_variable("HEADER_" "${INCLUDE}_PATH" HEADER_PATH)
+		find_path(${HEADER_PATH} "${INCLUDE}")
+		if(${HEADER_PATH})
+			list(APPEND CMAKE_REQUIRED_INCLUDES "${${HEADER_PATH}}")
+		endif()
+	endforeach()
+	check_include_files("${INCLUDES}" ${ARGN})
+endfunction()
+
 # Endianness
-check_include_files("endian.h" HAVE_ENDIAN_H)
-check_include_files("sys/endian.h" HAVE_SYS_ENDIAN_H)
+check_include_files_with_sysroot("endian.h" HAVE_ENDIAN_H)
+check_include_files_with_sysroot("sys/endian.h" HAVE_SYS_ENDIAN_H)
 
 if(HAVE_ENDIAN_H)
 	set(ENDIAN_FILE "endian.h")
@@ -44,15 +61,15 @@
 endif()
 
 # Byte swap
-check_include_files("byteswap.h" HAVE_BYTESWAP_H)
+check_include_files_with_sysroot("byteswap.h" HAVE_BYTESWAP_H)
 
 check_symbol_exists(bswap_16 "byteswap.h" HAVE_DECL_BSWAP_16)
 check_symbol_exists(bswap_32 "byteswap.h" HAVE_DECL_BSWAP_32)
 check_symbol_exists(bswap_64 "byteswap.h" HAVE_DECL_BSWAP_64)
 
 # sys/select.h and sys/prctl.h headers
-check_include_files("sys/select.h" HAVE_SYS_SELECT_H)
-check_include_files("sys/prctl.h" HAVE_SYS_PRCTL_H)
+check_include_files_with_sysroot("sys/select.h" HAVE_SYS_SELECT_H)
+check_include_files_with_sysroot("sys/prctl.h" HAVE_SYS_PRCTL_H)
 
 # Bitmanip intrinsics
 function(check_builtin_exist SYMBOL VARIABLE)