diff --git a/src/rpc/client.cpp b/src/rpc/client.cpp
--- a/src/rpc/client.cpp
+++ b/src/rpc/client.cpp
@@ -132,6 +132,7 @@
     {"setban", 2, "bantime"},
     {"setban", 3, "absolute"},
     {"setnetworkactive", 0, "state"},
+    {"setwalletflag", 1, "value"},
     {"getmempoolancestors", 1, "verbose"},
     {"getmempooldescendants", 1, "verbose"},
     {"disconnectnode", 1, "nodeid"},
diff --git a/src/wallet/rpcwallet.cpp b/src/wallet/rpcwallet.cpp
--- a/src/wallet/rpcwallet.cpp
+++ b/src/wallet/rpcwallet.cpp
@@ -3179,6 +3179,86 @@
     return obj;
 }
 
+static UniValue setwalletflag(const Config &config,
+                              const JSONRPCRequest &request) {
+    std::shared_ptr<CWallet> const wallet = GetWalletForJSONRPCRequest(request);
+    CWallet *const pwallet = wallet.get();
+
+    if (!EnsureWalletIsAvailable(pwallet, request.fHelp)) {
+        return NullUniValue;
+    }
+
+    if (request.fHelp || request.params.size() < 1 ||
+        request.params.size() > 2) {
+        std::string flags = "";
+        for (auto &it : WALLET_FLAG_MAP) {
+            if (it.second & MUTABLE_WALLET_FLAGS) {
+                flags += (flags == "" ? "" : ", ") + it.first;
+            }
+        }
+        throw std::runtime_error(RPCHelpMan{
+            "setwalletflag",
+            "\nChange the state of the given wallet flag for a wallet.\n",
+            {
+                {"flag", RPCArg::Type::STR, RPCArg::Optional::NO,
+                 "The name of the flag to change. Current available flags: " +
+                     flags},
+                {"value", RPCArg::Type::BOOL, /* default */ "true",
+                 "The new state."},
+            },
+            RPCResult{
+                "{\n"
+                "    \"flag_name\": string   (string) The name of the flag "
+                "that was modified\n"
+                "    \"flag_state\": bool    (bool) The new state of the flag\n"
+                "    \"warnings\": string    (string) Any warnings associated "
+                "with the change\n"
+                "}\n"},
+            RPCExamples{HelpExampleCli("setwalletflag", "avoid_reuse") +
+                        HelpExampleRpc("setwalletflag", "\"avoid_reuse\"")},
+        }
+                                     .ToString());
+    }
+
+    std::string flag_str = request.params[0].get_str();
+    bool value = request.params[1].isNull() || request.params[1].get_bool();
+
+    if (!WALLET_FLAG_MAP.count(flag_str)) {
+        throw JSONRPCError(RPC_INVALID_PARAMETER,
+                           strprintf("Unknown wallet flag: %s", flag_str));
+    }
+
+    auto flag = WALLET_FLAG_MAP.at(flag_str);
+
+    if (!(flag & MUTABLE_WALLET_FLAGS)) {
+        throw JSONRPCError(RPC_INVALID_PARAMETER,
+                           strprintf("Wallet flag is immutable: %s", flag_str));
+    }
+
+    UniValue res(UniValue::VOBJ);
+
+    if (pwallet->IsWalletFlagSet(flag) == value) {
+        throw JSONRPCError(RPC_INVALID_PARAMETER,
+                           strprintf("Wallet flag is already set to %s: %s",
+                                     value ? "true" : "false", flag_str));
+    }
+
+    res.pushKV("flag_name", flag_str);
+    res.pushKV("flag_state", value);
+
+    if (value) {
+        pwallet->SetWalletFlag(flag);
+    } else {
+        pwallet->UnsetWalletFlag(flag);
+    }
+
+    if (flag && value && WALLET_FLAG_CAVEATS.count(flag)) {
+        res.pushKV("warnings", WALLET_FLAG_CAVEATS.at(flag));
+    }
+
+    return res;
+}
+
 static UniValue createwallet(const Config &config,
                              const JSONRPCRequest &request) {
     const RPCHelpMan help{
@@ -4854,6 +4934,7 @@
     { "wallet",             "sethdseed",                    sethdseed,                    {"newkeypool","seed"} },
     { "wallet",             "setlabel",                     setlabel,                     {"address","label"} },
     { "wallet",             "settxfee",                     settxfee,                     {"amount"} },
+    { "wallet",             "setwalletflag",                setwalletflag,                {"flag","value"} },
     { "wallet",             "signmessage",                  signmessage,                  {"address","message"} },
     { "wallet",             "signrawtransactionwithwallet", signrawtransactionwithwallet, {"hextring","prevtxs","sighashtype"} },
     { "wallet",             "unloadwallet",                 unloadwallet,                 {"wallet_name"} },
diff --git a/src/wallet/wallet.h b/src/wallet/wallet.h
--- a/src/wallet/wallet.h
+++ b/src/wallet/wallet.h
@@ -163,6 +163,8 @@
     WALLET_FLAG_AVOID_REUSE | WALLET_FLAG_BLANK_WALLET |
     WALLET_FLAG_KEY_ORIGIN_METADATA | WALLET_FLAG_DISABLE_PRIVATE_KEYS;
 
+static constexpr uint64_t MUTABLE_WALLET_FLAGS = WALLET_FLAG_AVOID_REUSE;
+
 static const std::map<std::string, WalletFlags> WALLET_FLAG_MAP{
     {"avoid_reuse", WALLET_FLAG_AVOID_REUSE},
     {"blank", WALLET_FLAG_BLANK_WALLET},