diff --git a/test/functional/test_framework/test_framework.py b/test/functional/test_framework/test_framework.py
--- a/test/functional/test_framework/test_framework.py
+++ b/test/functional/test_framework/test_framework.py
@@ -10,6 +10,7 @@
 import logging
 import os
 import pdb
+import random
 import shutil
 import sys
 import tempfile
@@ -131,6 +132,8 @@
                             help="use bitcoin-cli instead of RPC for all commands")
         parser.add_argument("--perf", dest="perf", default=False, action="store_true",
                             help="profile running nodes with perf for the duration of the test")
+        parser.add_argument("--randomseed", type=int,
+                            help="set a random seed for deterministically reproducing a previous test run")
         parser.add_argument("--with-axionactivation", dest="axionactivation", default=False, action="store_true",
                             help="Activate axion update on timestamp {}".format(TIMESTAMP_IN_THE_PAST))
 
@@ -168,6 +171,22 @@
             self.options.tmpdir = tempfile.mkdtemp(prefix="test")
         self._start_logging()
 
+        # Seed the PRNG. Note that test runs are reproducible if and only if
+        # a single thread accesses the PRNG. For more information, see
+        # https://docs.python.org/3/library/random.html#notes-on-reproducibility.
+        # The network thread shouldn't access random. If we need to change the
+        # network thread to access randomness, it should instantiate its own
+        # random.Random object.
+        seed = self.options.randomseed
+
+        if seed is None:
+            seed = random.randrange(sys.maxsize)
+        else:
+            self.log.debug("User supplied random seed {}".format(seed))
+
+        random.seed(seed)
+        self.log.debug("PRNG seed is: {}".format(seed))
+
         self.log.debug('Setting up network thread')
         self.network_thread = NetworkThread()
         self.network_thread.start()