diff --git a/src/CMakeLists.txt b/src/CMakeLists.txt
--- a/src/CMakeLists.txt
+++ b/src/CMakeLists.txt
@@ -108,13 +108,15 @@
 	add_compiler_flags(-fstack-reuse=none)
 endif()
 
-# Ensure that WINDRES_PREPROC is enabled when using windres.
 if(${CMAKE_SYSTEM_NAME} MATCHES "Windows")
 	# Ensure that WINDRES_PREPROC is enabled when using windres.
 	list(APPEND CMAKE_RC_FLAGS "-DWINDRES_PREPROC")
 
 	# Build all static so there is no dll file to distribute.
 	add_linker_flags(-static)
+
+	# Windows 7
+	add_compile_definitions(_WIN32_WINNT=0x0601)
 endif()
 
 if(${CMAKE_SYSTEM_NAME} MATCHES "Darwin")
diff --git a/src/compat.h b/src/compat.h
--- a/src/compat.h
+++ b/src/compat.h
@@ -11,10 +11,6 @@
 #endif
 
 #ifdef WIN32
-#ifdef _WIN32_WINNT
-#undef _WIN32_WINNT
-#endif
-#define _WIN32_WINNT 0x0501
 #ifndef WIN32_LEAN_AND_MEAN
 #define WIN32_LEAN_AND_MEAN 1
 #endif
diff --git a/src/init.cpp b/src/init.cpp
--- a/src/init.cpp
+++ b/src/init.cpp
@@ -1583,21 +1583,8 @@
     _set_abort_behavior(0, _WRITE_ABORT_MSG | _CALL_REPORTFAULT);
 #endif
 #ifdef WIN32
-// Enable Data Execution Prevention (DEP)
-// Minimum supported OS versions: WinXP SP3, WinVista >= SP1, Win Server 2008
-// A failure is non-critical and needs no further attention!
-#ifndef PROCESS_DEP_ENABLE
-// We define this here, because GCCs winbase.h limits this to _WIN32_WINNT >=
-// 0x0601 (Windows 7), which is not correct. Can be removed, when GCCs winbase.h
-// is fixed!
-#define PROCESS_DEP_ENABLE 0x00000001
-#endif
-    typedef BOOL(WINAPI * PSETPROCDEPPOL)(DWORD);
-    PSETPROCDEPPOL setProcDEPPol = (PSETPROCDEPPOL)GetProcAddress(
-        GetModuleHandleA("Kernel32.dll"), "SetProcessDEPPolicy");
-    if (setProcDEPPol != nullptr) {
-        setProcDEPPol(PROCESS_DEP_ENABLE);
-    }
+    // Enable Data Execution Prevention (DEP)
+    SetProcessDEPPolicy(PROCESS_DEP_ENABLE);
 #endif
 
     if (!SetupNetworking()) {
diff --git a/src/leveldb/CMakeLists.txt b/src/leveldb/CMakeLists.txt
--- a/src/leveldb/CMakeLists.txt
+++ b/src/leveldb/CMakeLists.txt
@@ -84,7 +84,6 @@
 	)
 	target_compile_definitions(leveldb
 		PRIVATE
-			WINVER=0x0500
 			__USE_MINGW_ANSI_STDIO=1
 	)
 
diff --git a/src/net.cpp b/src/net.cpp
--- a/src/net.cpp
+++ b/src/net.cpp
@@ -59,18 +59,6 @@
 #define MSG_DONTWAIT 0
 #endif
 
-// Fix for ancient MinGW versions, that don't have defined these in ws2tcpip.h.
-// Todo: Can be removed when our pull-tester is upgraded to a modern MinGW
-// version.
-#ifdef WIN32
-#ifndef PROTECTION_LEVEL_UNRESTRICTED
-#define PROTECTION_LEVEL_UNRESTRICTED 10
-#endif
-#ifndef IPV6_PROTECTION_LEVEL
-#define IPV6_PROTECTION_LEVEL 23
-#endif
-#endif
-
 /** Used to pass flags to the Bind() function */
 enum BindFlags {
     BF_NONE = 0,
diff --git a/src/netbase.cpp b/src/netbase.cpp
--- a/src/netbase.cpp
+++ b/src/netbase.cpp
@@ -95,9 +95,6 @@
     aiHint.ai_protocol = IPPROTO_TCP;
     // We don't care which address family (IPv4 or IPv6) is returned
     aiHint.ai_family = AF_UNSPEC;
-#ifdef WIN32
-    aiHint.ai_flags = fAllowLookup ? 0 : AI_NUMERICHOST;
-#else
     // If we allow lookups of hostnames, use the AI_ADDRCONFIG flag to only
     // return addresses whose family we have an address configured for.
     //
@@ -105,7 +102,6 @@
     // getaddrinfo to only decode numerical network addresses and suppress
     // hostname lookups.
     aiHint.ai_flags = fAllowLookup ? AI_ADDRCONFIG : AI_NUMERICHOST;
-#endif
     struct addrinfo *aiRes = nullptr;
     int nErr = getaddrinfo(pszName, nullptr, &aiHint, &aiRes);
     if (nErr) {
diff --git a/src/qt/guiutil.cpp b/src/qt/guiutil.cpp
--- a/src/qt/guiutil.cpp
+++ b/src/qt/guiutil.cpp
@@ -21,10 +21,6 @@
 #include <util/system.h>
 
 #ifdef WIN32
-#ifdef _WIN32_WINNT
-#undef _WIN32_WINNT
-#endif
-#define _WIN32_WINNT 0x0501
 #ifdef _WIN32_IE
 #undef _WIN32_IE
 #endif
diff --git a/src/support/lockedpool.cpp b/src/support/lockedpool.cpp
--- a/src/support/lockedpool.cpp
+++ b/src/support/lockedpool.cpp
@@ -10,10 +10,6 @@
 #endif
 
 #ifdef WIN32
-#ifdef _WIN32_WINNT
-#undef _WIN32_WINNT
-#endif
-#define _WIN32_WINNT 0x0501
 #define WIN32_LEAN_AND_MEAN 1
 #ifndef NOMINMAX
 #define NOMINMAX
diff --git a/src/util/system.cpp b/src/util/system.cpp
--- a/src/util/system.cpp
+++ b/src/util/system.cpp
@@ -49,11 +49,6 @@
 #pragma warning(disable : 4717)
 #endif
 
-#ifdef _WIN32_WINNT
-#undef _WIN32_WINNT
-#endif
-#define _WIN32_WINNT 0x0501
-
 #ifdef _WIN32_IE
 #undef _WIN32_IE
 #endif