diff --git a/test/functional/interface_rpc.py b/test/functional/interface_rpc.py
--- a/test/functional/interface_rpc.py
+++ b/test/functional/interface_rpc.py
@@ -1,13 +1,25 @@
 #!/usr/bin/env python3
-# Copyright (c) 2018 The Bitcoin Core developers
+# Copyright (c) 2018-2019 The Bitcoin Core developers
 # Distributed under the MIT software license, see the accompanying
 # file COPYING or http://www.opensource.org/licenses/mit-license.php.
 """Tests some generic aspects of the RPC interface."""
 
+from test_framework.authproxy import JSONRPCException
 from test_framework.test_framework import BitcoinTestFramework
 from test_framework.util import assert_equal, assert_greater_than_or_equal
 
 
+def expect_http_status(expected_http_status, expected_rpc_code,
+                       fcn, *args):
+    try:
+        fcn(*args)
+        raise AssertionError(
+            "Expected RPC error {}, got none".format(expected_rpc_code))
+    except JSONRPCException as exc:
+        assert_equal(exc.error["code"], expected_rpc_code)
+        assert_equal(exc.http_status, expected_http_status)
+
+
 class RPCInterfaceTest(BitcoinTestFramework):
     def set_test_params(self):
         self.num_nodes = 1
@@ -49,9 +61,16 @@
         assert_equal(result_by_id[3]['error'], None)
         assert result_by_id[3]['result'] is not None
 
+    def test_http_status_codes(self):
+        self.log.info("Testing HTTP status codes for JSON-RPC requests...")
+
+        expect_http_status(404, -32601, self.nodes[0].invalidmethod)
+        expect_http_status(500, -8, self.nodes[0].getblockhash, 42)
+
     def run_test(self):
         self.test_getrpcinfo()
         self.test_batch_request()
+        self.test_http_status_codes()
 
 
 if __name__ == '__main__':
diff --git a/test/functional/test_framework/authproxy.py b/test/functional/test_framework/authproxy.py
--- a/test/functional/test_framework/authproxy.py
+++ b/test/functional/test_framework/authproxy.py
@@ -36,6 +36,7 @@
 
 import base64
 import decimal
+from http import HTTPStatus
 import http.client
 import json
 import logging
@@ -51,13 +52,14 @@
 
 
 class JSONRPCException(Exception):
-    def __init__(self, rpc_error):
+    def __init__(self, rpc_error, http_status=None):
         try:
             errmsg = '{} ({})'.format(rpc_error['message'], rpc_error['code'])
         except (KeyError, TypeError):
             errmsg = ''
         super().__init__(errmsg)
         self.error = rpc_error
+        self.http_status = http_status
 
 
 def EncodeDecimal(o):
@@ -146,13 +148,16 @@
     def __call__(self, *args, **argsn):
         postdata = json.dumps(self.get_request(
             *args, **argsn), default=EncodeDecimal, ensure_ascii=self.ensure_ascii)
-        response = self._request(
+        response, status = self._request(
             'POST', self.__url.path, postdata.encode('utf-8'))
         if response['error'] is not None:
-            raise JSONRPCException(response['error'])
+            raise JSONRPCException(response['error'], status)
         elif 'result' not in response:
             raise JSONRPCException({
-                'code': -343, 'message': 'missing JSON-RPC result'})
+                'code': -343, 'message': 'missing JSON-RPC result'}, status)
+        elif status != HTTPStatus.OK:
+            raise JSONRPCException({
+                'code': -342, 'message': 'non-200 HTTP status code but no JSON-RPC error'}, status)
         else:
             return response['result']
 
@@ -160,7 +165,12 @@
         postdata = json.dumps(
             list(rpc_call_list), default=EncodeDecimal, ensure_ascii=self.ensure_ascii)
         log.debug("--> " + postdata)
-        return self._request('POST', self.__url.path, postdata.encode('utf-8'))
+        response, status = self._request(
+            'POST', self.__url.path, postdata.encode('utf-8'))
+        if status != HTTPStatus.OK:
+            raise JSONRPCException({
+                'code': -342, 'message': 'non-200 HTTP status code but no JSON-RPC error'}, status)
+        return response
 
     def _get_response(self):
         req_start_time = time.time()
@@ -179,9 +189,11 @@
 
         content_type = http_response.getheader('Content-Type')
         if content_type != 'application/json':
-            raise JSONRPCException({
-                'code': -342, 'message': 'non-JSON HTTP response with \'{} {}\' from server'.format(
-                    http_response.status, http_response.reason)})
+            raise JSONRPCException(
+                {'code': -342,
+                 'message': 'non-JSON HTTP response with \'{} {}\' from server'.format(
+                     http_response.status, http_response.reason)},
+                http_response.status)
 
         responsedata = http_response.read().decode('utf8')
         response = json.loads(responsedata, parse_float=decimal.Decimal)
@@ -191,7 +203,7 @@
                 response["result"], default=EncodeDecimal, ensure_ascii=self.ensure_ascii)))
         else:
             log.debug("<-- [{:.6f}] {}".format(elapsed, responsedata))
-        return response
+        return response, http_response.status
 
     def __truediv__(self, relative_uri):
         return AuthServiceProxy("{}/{}".format(self.__service_url,