diff --git a/depends/Makefile b/depends/Makefile
--- a/depends/Makefile
+++ b/depends/Makefile
@@ -123,6 +123,11 @@
 $(host_arch)_$(host_os)_id_string+=$(shell $(host_RANLIB) --version 2>/dev/null)
 $(host_arch)_$(host_os)_id_string+=$(shell $(host_STRIP) --version 2>/dev/null)
 
+ifneq ($(strip $(FORCE_USE_SYSTEM_CLANG)),)
+build_id_string+=system_clang
+$(host_arch)_$(host_os)_id_string+=system_clang
+endif
+
 qrencode_packages_$(NO_QR) = $(qrencode_packages)
 
 qt_packages_$(NO_QT) = $(qt_packages) $(qt_$(host_os)_packages) $(qt_$(host_arch)_$(host_os)_packages) $(qrencode_packages_)
@@ -155,6 +160,7 @@
 
 meta_depends = Makefile funcs.mk builders/default.mk hosts/default.mk hosts/$(host_os).mk builders/$(build_os).mk
 
+$(host_arch)_$(host_os)_native_binutils?=$($(host_os)_native_binutils)
 $(host_arch)_$(host_os)_native_toolchain?=$($(host_os)_native_toolchain)
 
 include funcs.mk
diff --git a/depends/README.md b/depends/README.md
--- a/depends/README.md
+++ b/depends/README.md
@@ -78,23 +78,44 @@
 
 ### Dependency Options
 
-The following can be set when running make: make FOO=bar
-
-    SOURCES_PATH: downloaded sources will be placed here
-    BASE_CACHE: built packages will be placed here
-    SDK_PATH: Path where sdk's can be found (used by macOS)
-    FALLBACK_DOWNLOAD_PATH: If a source file can't be fetched, try here before giving up
-    NO_QT: Don't download/build/cache qt and its dependencies
-    NO_QR: Don't download/build/cache packages needed for enabling qrencode
-    NO_ZMQ: Don't download/build/cache packages needed for enabling zeromq
-    NO_WALLET: Don't download/build/cache libs needed to enable the wallet
-    NO_UPNP: Don't download/build/cache packages needed for enabling upnp
-    NO_JEMALLOC: Don't download/build/cache jemalloc
-    DEBUG: disable some optimizations and enable more runtime checking
-    NO_PROTOBUF: Don't download/build/cache protobuf (used for BIP70 support)
-    HOST_ID_SALT: Optional salt to use when generating host package ids
-    BUILD_ID_SALT: Optional salt to use when generating build package ids
-    JOBS: Number of jobs to use for each package build
+The following can be set when running make: `make FOO=bar`
+
+<dl>
+<dt>SOURCES_PATH</dt>
+<dd>downloaded sources will be placed here</dd>
+<dt>BASE_CACHE</dt>
+<dd>built packages will be placed here</dd>
+<dt>SDK_PATH</dt>
+<dd>Path where sdk's can be found (used by macOS)</dd>
+<dt>FALLBACK_DOWNLOAD_PATH</dt>
+<dd>If a source file can't be fetched, try here before giving up</dd>
+<dt>NO_QT</dt>
+<dd>Don't download/build/cache qt and its dependencies</dd>
+<dt>NO_QR</dt>
+<dd>Don't download/build/cache packages needed for enabling qrencode</dd>
+<dt>NO_ZMQ</dt>
+<dd>Don't download/build/cache packages needed for enabling zeromq</dd>
+<dt>NO_WALLET</dt>
+<dd>Don't download/build/cache libs needed to enable the wallet</dd>
+<dt>NO_UPNP</dt>
+<dd>Don't download/build/cache packages needed for enabling upnp</dd>
+<dt>NO_JEMALLOC</dt>
+<dd>Don't download/build/cache jemalloc</dd>
+<dt>DEBUG</dt>
+<dd>disable some optimizations and enable more runtime checking</dd>
+<dt>NO_PROTOBUF</dt>
+<dd>Don't download/build/cache protobuf (used for BIP70 support)</dd>
+<dt>HOST_ID_SALT</dt>
+<dd>Optional salt to use when generating host package ids</dd>
+<dt>BUILD_ID_SALT</dt>
+<dd>Optional salt to use when generating build package ids</dd>
+<dt>JOBS</dt>
+<dd>Number of jobs to use for each package build</dd>
+<dt>FORCE_USE_SYSTEM_CLANG</dt>
+<dd>(EXPERTS ONLY) When cross-compiling for macOS, use clang found in the
+ system's <code>$PATH</code> rather than the default prebuilt release of clang
+ from llvm.org</dd>
+</dl>
 
 If some packages are not built, for example by building the depends with
 `make NO_WALLET=1`, the appropriate options should be set when building Bitcoin
diff --git a/depends/builders/darwin.mk b/depends/builders/darwin.mk
--- a/depends/builders/darwin.mk
+++ b/depends/builders/darwin.mk
@@ -19,4 +19,5 @@
 darwin_OTOOL:=$(shell xcrun -f otool)
 darwin_NM:=$(shell xcrun -f nm)
 darwin_INSTALL_NAME_TOOL:=$(shell xcrun -f install_name_tool)
+darwin_native_binutils=
 darwin_native_toolchain=
diff --git a/depends/funcs.mk b/depends/funcs.mk
--- a/depends/funcs.mk
+++ b/depends/funcs.mk
@@ -41,7 +41,7 @@
 
 define int_get_build_id
 $(eval $(1)_dependencies += $($(1)_$(host_arch)_$(host_os)_dependencies) $($(1)_$(host_os)_dependencies))
-$(eval $(1)_all_dependencies:=$(call int_get_all_dependencies,$(1),$($($(1)_type)_native_toolchain) $($(1)_dependencies)))
+$(eval $(1)_all_dependencies:=$(call int_get_all_dependencies,$(1),$($($(1)_type)_native_toolchain) $($($(1)_type)_native_binutils) $($(1)_dependencies)))
 $(foreach dep,$($(1)_all_dependencies),$(eval $(1)_build_id_deps+=$(dep)-$($(dep)_version)-$($(dep)_recipe_hash)))
 $(eval $(1)_build_id_long:=$(1)-$($(1)_version)-$($(1)_recipe_hash)-$(release_type) $($(1)_build_id_deps) $($($(1)_type)_id_string))
 $(eval $(1)_build_id:=$(shell echo -n "$($(1)_build_id_long)" | $(build_SHA256SUM) | cut -c-$(HASH_LENGTH)))
@@ -251,4 +251,4 @@
 $(foreach package,$(all_packages),$(eval $(call int_add_cmds,$(package))))
 
 #special exception: if a toolchain package exists, all non-native packages depend on it
-$(foreach package,$(packages),$(eval $($(package)_unpacked): |$($($(host_arch)_$(host_os)_native_toolchain)_cached) ))
+$(foreach package,$(packages),$(eval $($(package)_unpacked): |$($($(host_arch)_$(host_os)_native_toolchain)_cached) $($($(host_arch)_$(host_os)_native_binutils)_cached) ))
diff --git a/depends/hosts/darwin.mk b/depends/hosts/darwin.mk
--- a/depends/hosts/darwin.mk
+++ b/depends/hosts/darwin.mk
@@ -6,10 +6,30 @@
 
 OSX_SDK=$(SDK_PATH)/Xcode-$(XCODE_VERSION)-$(XCODE_BUILD_ID)-extracted-SDK-with-libcxx-headers
 
-# When cross-compiling for Darwin using Clang, -mlinker-version must be passed to
-# ensure that modern linker features are enabled.
-darwin_CC=clang -target $(host) -mmacosx-version-min=$(OSX_MIN_VERSION) --sysroot $(OSX_SDK) -mlinker-version=$(LD64_VERSION)
-darwin_CXX=clang++ -target $(host) -mmacosx-version-min=$(OSX_MIN_VERSION) --sysroot $(OSX_SDK) -stdlib=libc++ -mlinker-version=$(LD64_VERSION)
+# Flag explanations:
+#
+#     -mlinker-version
+#
+#         Ensures that modern linker features are enabled. See here for more
+#         details: https://github.com/bitcoin/bitcoin/pull/19407.
+#
+#     -B$(build_prefix)/bin
+#
+#         Explicitly point to our binaries (e.g. cctools) so that they are
+#         ensured to be found and preferred over other possibilities.
+#
+#     -nostdinc++ -isystem $(OSX_SDK)/usr/include/c++/v1
+#
+#         Forces clang to use the libc++ headers from our SDK and completely
+#         forget about the libc++ headers from the standard directories
+#
+#         TODO: Once we start requiring a clang version that has the
+#         -stdlib++-isystem<directory> flag first introduced here:
+#         https://reviews.llvm.org/D64089, we should use that instead. Read the
+#         differential summary there for more details.
+#
+darwin_CC=clang -target $(host) -mmacosx-version-min=$(OSX_MIN_VERSION) --sysroot $(OSX_SDK) -mlinker-version=$(LD64_VERSION) -B$(build_prefix)/bin
+darwin_CXX=clang++ -target $(host) -mmacosx-version-min=$(OSX_MIN_VERSION) --sysroot $(OSX_SDK) -stdlib=libc++ -mlinker-version=$(LD64_VERSION) -B$(build_prefix)/bin -nostdinc++ -isystem $(OSX_SDK)/usr/include/c++/v1
 
 darwin_CFLAGS=-pipe
 darwin_CXXFLAGS=$(darwin_CFLAGS)
@@ -20,4 +40,9 @@
 darwin_debug_CFLAGS=-O1
 darwin_debug_CXXFLAGS=$(darwin_debug_CFLAGS)
 
+darwin_native_binutils=native_cctools
+ifeq ($(strip $(FORCE_USE_SYSTEM_CLANG)),)
 darwin_native_toolchain=native_cctools
+else
+darwin_native_toolchain=
+endif
diff --git a/depends/packages/native_cctools.mk b/depends/packages/native_cctools.mk
--- a/depends/packages/native_cctools.mk
+++ b/depends/packages/native_cctools.mk
@@ -6,11 +6,13 @@
 $(package)_build_subdir=cctools
 $(package)_patches=ld64_disable_threading.patch
 
+ifeq ($(strip $(FORCE_USE_SYSTEM_CLANG)),)
 $(package)_clang_version=8.0.0
 $(package)_clang_download_path=https://releases.llvm.org/$($(package)_clang_version)
 $(package)_clang_download_file=clang+llvm-$($(package)_clang_version)-x86_64-linux-gnu-ubuntu-16.04.tar.xz
 $(package)_clang_file_name=clang-llvm-$($(package)_clang_version)-x86_64-linux-gnu-ubuntu-16.04.tar.xz
 $(package)_clang_sha256_hash=87b88d620284d1f0573923e6f7cc89edccf11d19ebaec1cfb83b4f09ac5db09c
+endif
 
 $(package)_libtapi_version=3efb201881e7a76a21e0554906cf306432539cef
 $(package)_libtapi_download_path=https://github.com/tpoechtrager/apple-libtapi/archive
@@ -18,15 +20,25 @@
 $(package)_libtapi_file_name=$($(package)_libtapi_version).tar.gz
 $(package)_libtapi_sha256_hash=380c1ca37cfa04a8699d0887a8d3ee1ad27f3d08baba78887c73b09485c0fbd3
 
-$(package)_extra_sources=$($(package)_clang_file_name)
-$(package)_extra_sources += $($(package)_libtapi_file_name)
+$(package)_extra_sources=$($(package)_libtapi_file_name)
+ifeq ($(strip $(FORCE_USE_SYSTEM_CLANG)),)
+$(package)_extra_sources += $($(package)_clang_file_name)
+endif
 
+ifeq ($(strip $(FORCE_USE_SYSTEM_CLANG)),)
 define $(package)_fetch_cmds
 $(call fetch_file,$(package),$($(package)_download_path),$($(package)_download_file),$($(package)_file_name),$($(package)_sha256_hash)) && \
 $(call fetch_file,$(package),$($(package)_clang_download_path),$($(package)_clang_download_file),$($(package)_clang_file_name),$($(package)_clang_sha256_hash)) && \
 $(call fetch_file,$(package),$($(package)_libtapi_download_path),$($(package)_libtapi_download_file),$($(package)_libtapi_file_name),$($(package)_libtapi_sha256_hash))
 endef
+else
+define $(package)_fetch_cmds
+$(call fetch_file,$(package),$($(package)_download_path),$($(package)_download_file),$($(package)_file_name),$($(package)_sha256_hash)) && \
+$(call fetch_file,$(package),$($(package)_libtapi_download_path),$($(package)_libtapi_download_file),$($(package)_libtapi_file_name),$($(package)_libtapi_sha256_hash))
+endef
+endif
 
+ifeq ($(strip $(FORCE_USE_SYSTEM_CLANG)),)
 define $(package)_extract_cmds
   mkdir -p $($(package)_extract_dir) && \
   echo "$($(package)_sha256_hash)  $($(package)_source)" > $($(package)_extract_dir)/.$($(package)_file_name).hash && \
@@ -40,12 +52,28 @@
   rm -f toolchain/lib/libc++abi.so* && \
   tar --no-same-owner --strip-components=1 -xf $($(package)_source)
 endef
+else
+define $(package)_extract_cmds
+  mkdir -p $($(package)_extract_dir) && \
+  echo "$($(package)_sha256_hash)  $($(package)_source)" > $($(package)_extract_dir)/.$($(package)_file_name).hash && \
+  echo "$($(package)_libtapi_sha256_hash)  $($(package)_source_dir)/$($(package)_libtapi_file_name)" >> $($(package)_extract_dir)/.$($(package)_file_name).hash && \
+  $(build_SHA256SUM) -c $($(package)_extract_dir)/.$($(package)_file_name).hash && \
+  mkdir -p libtapi && \
+  tar --no-same-owner --strip-components=1 -C libtapi -xf $($(package)_source_dir)/$($(package)_libtapi_file_name) && \
+  tar --no-same-owner --strip-components=1 -xf $($(package)_source)
+endef
+endif
 
 define $(package)_set_vars
   $(package)_config_opts=--target=$(host) --disable-lto-support --with-libtapi=$($(package)_extract_dir)
   $(package)_ldflags+=-Wl,-rpath=\\$$$$$$$$\$$$$$$$$ORIGIN/../lib
+  ifeq ($(strip $(FORCE_USE_SYSTEM_CLANG)),)
   $(package)_cc=$($(package)_extract_dir)/toolchain/bin/clang
   $(package)_cxx=$($(package)_extract_dir)/toolchain/bin/clang++
+  else
+  $(package)_cc=clang
+  $(package)_cxx=clang++
+  endif
 endef
 
 define $(package)_preprocess_cmds
@@ -62,6 +90,7 @@
   $(MAKE) -j$(JOBS)
 endef
 
+ifeq ($(strip $(FORCE_USE_SYSTEM_CLANG)),)
 define $(package)_stage_cmds
   $(MAKE) DESTDIR=$($(package)_staging_dir) install && \
   mkdir -p $($(package)_staging_prefix_dir)/lib/ && \
@@ -76,3 +105,11 @@
   cp -rf lib/clang/$($(package)_clang_version)/include/* $($(package)_staging_prefix_dir)/lib/clang/$($(package)_clang_version)/include/ && \
   cp bin/dsymutil $($(package)_staging_prefix_dir)/bin/$(host)-dsymutil
 endef
+else
+define $(package)_stage_cmds
+  $(MAKE) DESTDIR=$($(package)_staging_dir) install && \
+  mkdir -p $($(package)_staging_prefix_dir)/lib/ && \
+  cd $($(package)_extract_dir) && \
+  cp lib/libtapi.so.6 $($(package)_staging_prefix_dir)/lib/
+endef
+endif