diff --git a/src/init.cpp b/src/init.cpp
--- a/src/init.cpp
+++ b/src/init.cpp
@@ -2563,7 +2563,7 @@
                 chainman.m_total_coinstip_cache = nCoinCacheUsage;
                 chainman.m_total_coinsdb_cache = nCoinDBCache;
 
-                UnloadBlockIndex();
+                UnloadBlockIndex(node.mempool);
 
                 // new CBlockTreeDB tries to delete the existing file, which
                 // fails if it's still open from the previous loop. Close it
diff --git a/src/qt/test/apptests.cpp b/src/qt/test/apptests.cpp
--- a/src/qt/test/apptests.cpp
+++ b/src/qt/test/apptests.cpp
@@ -105,7 +105,7 @@
     // Reset global state to avoid interfering with later tests.
     LogInstance().DisconnectTestLogger();
     AbortShutdown();
-    UnloadBlockIndex();
+    UnloadBlockIndex(/* mempool */ nullptr);
     WITH_LOCK(::cs_main, g_chainman.Reset());
 }
 
diff --git a/src/test/util/setup_common.cpp b/src/test/util/setup_common.cpp
--- a/src/test/util/setup_common.cpp
+++ b/src/test/util/setup_common.cpp
@@ -228,9 +228,9 @@
     m_node.connman.reset();
     m_node.banman.reset();
     m_node.args = nullptr;
+    UnloadBlockIndex(m_node.mempool);
     m_node.mempool = nullptr;
     m_node.scheduler.reset();
-    UnloadBlockIndex();
     m_node.chainman->Reset();
     m_node.chainman = nullptr;
     pblocktree.reset();
diff --git a/src/validation.h b/src/validation.h
--- a/src/validation.h
+++ b/src/validation.h
@@ -225,7 +225,7 @@
 /**
  * Unload database information.
  */
-void UnloadBlockIndex();
+void UnloadBlockIndex(CTxMemPool *mempool);
 
 /**
  * Run an instance of the script checking thread.
diff --git a/src/validation.cpp b/src/validation.cpp
--- a/src/validation.cpp
+++ b/src/validation.cpp
@@ -5193,7 +5193,7 @@
 // May NOT be used after any connections are up as much
 // of the peer-processing logic assumes a consistent
 // block index state
-void UnloadBlockIndex() {
+void UnloadBlockIndex(CTxMemPool *mempool) {
     LOCK(cs_main);
     g_chainman.Unload();
     pindexBestInvalid = nullptr;
@@ -5202,7 +5202,9 @@
     pindexBestForkTip = nullptr;
     pindexBestForkBase = nullptr;
     ResetASERTAnchorBlockCache();
-    g_mempool.clear();
+    if (mempool) {
+        mempool->clear();
+    }
     vinfoBlockFile.clear();
     nLastBlockFile = 0;
     setDirtyBlockIndex.clear();