diff --git a/src/util/system.cpp b/src/util/system.cpp
--- a/src/util/system.cpp
+++ b/src/util/system.cpp
@@ -321,6 +321,17 @@
 
     for (int i = 1; i < argc; i++) {
         std::string key(argv[i]);
+
+#ifdef MAC_OSX
+        // At the first time when a user gets the "App downloaded from the
+        // internet" warning, and clicks the Open button, macOS passes
+        // a unique process serial number (PSN) as -psn_... command-line
+        // argument, which we filter out.
+        if (key.substr(0, 5) == "-psn_") {
+            continue;
+        }
+#endif
+
         if (key == "-") {
             // bitcoin-tx using stdin
             break;