diff --git a/src/wallet/walletdb.cpp b/src/wallet/walletdb.cpp
--- a/src/wallet/walletdb.cpp
+++ b/src/wallet/walletdb.cpp
@@ -664,9 +664,6 @@
             ssValue >> ser_xpub;
             CExtPubKey xpub;
             xpub.Decode(ser_xpub.data());
-            if (wss.m_descriptor_caches.count(desc_id)) {
-                wss.m_descriptor_caches[desc_id] = DescriptorCache();
-            }
             if (parent) {
                 wss.m_descriptor_caches[desc_id].CacheParentExtPubKey(
                     key_exp_index, xpub);
diff --git a/test/functional/wallet_importdescriptors.py b/test/functional/wallet_importdescriptors.py
--- a/test/functional/wallet_importdescriptors.py
+++ b/test/functional/wallet_importdescriptors.py
@@ -120,6 +120,14 @@
 
         assert_equal(w1.getwalletinfo()['keypoolsize'], 0)
 
+        test_address(w1,
+                     key.p2pkh_addr,
+                     ismine=True,
+                     solvable=True)
+
+        # Check persistence of data and that loading works correctly
+        w1.unloadwallet()
+        self.nodes[1].loadwallet('w1')
         test_address(w1,
                      key.p2pkh_addr,
                      ismine=True,
@@ -372,6 +380,11 @@
         self.sync_all()
         assert_equal(wmulti_pub.getbalance(), wmulti_priv.getbalance())
 
+        # Make sure that descriptor wallets containing multiple xpubs in a
+        # single descriptor load correctly
+        wmulti_pub.unloadwallet()
+        self.nodes[1].loadwallet('wmulti_pub')
+
         self.log.info("Multisig with distributed keys")
         self.nodes[1].createwallet(
             wallet_name="wmulti_priv1",